Comparative genomics has shown that ray finned fish (Actinopterygii) contain more copies of many genes than other vertebrates. A large number of these additional genes appear to have been produced during a genome duplication event that occurred early during the evolution of Actinopterygii (i.e., before the teleost radiation). In addition to this ancient genome duplication event, many lineages within Actinopterygii have experienced more recent genome duplications. The database named Wanda lists groups of orthologous genes with one copy from man, mouse and chicken, one or two from tetraploid Xenopus, and two or more ancient copies (i.e., paralogs) from ray finned fish. The database also contains the sequence alignments and phylogenetic trees that were necessary for determining the correct orthologous and paralogous relationships among genes. Where available, map positions and functional data are also reported. The Wanda database should be of particular use to evolutionary and developmental biologists who are interested in the evolutionary and functional divergence of genes after duplication.
Van de Peer I., Taylor J.S., Joseph J., Meyer A. (2002) Nucl. Acids Res., 30, 109-112.
Адрес: http://www.evolutionsbiologie.uni-konstanz.de/Wanda/
См. также:
TTD - Therapeutic Target Database
UDB - the Unified DataBase for Human Genome Mapping
UniGene
UniProt - the Universal Protein knowledgebase
Vertebrate MitBASE - a dataBASE on Vertebrate Mitochondrial DNA sequences
Virgil - Virgil database for rich links
WormBase
YPD - Yeast Proteome Database
Z Curve Database - Z Curve Database of Genomes
ZFIN - The Zebrafish Information Network
...
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