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Акифьев А. П., Потапенко А. И. Биоэсхатология: основные направления и первые результаты исследований// Успехи геронтол. 1997. Т. I. С. 41-46.

Алтухов Ю. П. Гетерозиготность генома, скорость полового созревания и продолжительность жизни // Докл. РАН. 1996. Т. 348. С. 842-845.

Алтухов Ю. П., Шереметева В. А. Геномная гетерозиготность и продолжительность жизни человека//Докл. РАН. 2000. Т. 371. С. 197-199.

Анисимов В. И. Спонтанные опухоли у крыс различных линий // Вопр. онкол. 1976. № 8. С. 98-110.

Анисимов В. И. Изменения уровня биогенных аминов в головном мозге лабораторных животных и человека в процессе развития и старения // Успехи физиол. наук. 1979. Т. 10, №1. С. 54-75.

 

Анисимов В. Н. Влияние буформина и дифенина на продолжительность жизни, зстральную функцию и частоту спонтанных опухолей у самок крыс // Вопр. онкол. 1980. Т. 26, № 6. С. 42-48.

 

Анисимов В. И. Возрастные изменения чувствительности к канцерогенам и профилактика рака // Вести. АМН СССР. 1989. № 8. С. 84-92.

Анисимов В. Н. Канцерогенез и онтогенез: основные направления и результаты исследований // Вопр. онкол. 1997. Т. .43. С. 88-94.

Анисимов В. И. Роль индуцируемой 5-бромодезоксиуридиьом нестабильности генома в механизмах ускоренного старения и канцерогенеза // Успехи геронтол. 1997а. Т. I. С. 50-56.

 

Анисимов В. И. Физиологические функции эпифиза (геронтологический аспект)//Рос. физиол. журн. им. И. М. Сеченова. 1998. Т. 83, №8. С. 1-10.

Анисимов В. И. Геронтологическое общество при Российской академии наук // Рос. физиол. журн. им. И. М. Сеченова. 2000. Т. 85, № 10. С. 1355-1362.

Анисимов В. Н. Современные представления о природе старения // Успехи соврем, биол. 2000а. Т. 120, С. 146-164.

Анисимов В. N. Старение и канцерогенез // Успехи геронтол. 2002. Т. 10. С. 99-125.

Анисимов В. И. "Игра в бисер" для биологов или наука послезавтра? // Биохимия. 2003. Т. 68. С. 292-298.

Анисимов В. И. Приоритетные направления фундаментальных исследований в геронтологии: вклад России // Успехи геронтол. 2003. Т. 12. С. 9-27.

Анисимов В. Н., Жуковская Н, В, Влияние возраста на рост перевиваемых опухолей у мышей// Вопр. онкол. J981. Т. 27,№8. С. 52-59.

Анисимов В. И., Кондрашова М. Н. Влияние янтарной кислоты на частоту спонтанных опухолей и продолжительность жизни у мышей СЗН/Sn // Докл. АН СССР. 1979.Т.248.С. 1242-L245.

 

Анисимов В. Н., Лазебник Л. Б. Состояние и перспективы развития геронтологической науки в России // Успехи геронтол. 1997. Т. 1 С. 9-15.

Анисимов В. Н., Соловьев М, В. Эволюция концепций в геронтологии. СПб.: Эскулап, 1999. 130 с.

Анисимов В. И., Хавинсон В. X. Влияние полипептидного препарата эпифиза на продолжительность жизни и частоту спонтанных опухолей у старых самок крыс // Докл. АН СССР. 1991. Т. 319. С. 250 - 253.

 

Анисимов В. И., Шешо Е. В. Канцерогенез кожи, индуцированный неонатальным введением 5-бромо-2'-дезоксиуридина и последующим воздействием 12-0-тетрадеканоилфорбол-13-ацетата у мышей // Вопр. онкол. 1996. Т. 42, № I. С. 82-84.

 

Анисимов В, Н., Хавинсон В. X., Морозов В. Г., Дильман В. М, Снижение порога чувствительности гипоталамо-гипофизарной системы к действию эстрогенов под влиянием экстракта эпифиза у старых самок крыс // Докл. АН СССР. 1973. Т. 213. С.483-486.

 

Анисимов В, Н., Лихачев А, Я" Напалков Н, П. Возникновение злокачественных опухолей у животных вследствие включения синтетического пиримидинового основания 5-6ромо-2'-дезоксиуридина в ДНК // Вопр. онкол. 1998. Т. 44. С. 19-22.

 

Анисимов В. И., Прокопенко В. М., Хавинсон В, X. Мелатонин и эпиталамин угнетают процесс свободно-радикального окисления у крыс//Докл. РАН. 1995. Т. 343. С. 557-559.

 

Анисимов В. И.г Арутюнян А. В., Опарина Т. И. и др. Возрастные изменения активности свободнорадикальных процессов в тканях и сыворотке крови крыс // Рос. физиол. журн. им. И. М. Сеченова. 1999. Т. 84. С. 502- 507.

 

Анисимов С. В., Богилер К, Р., Анисимов В, Н. Изучение влияния мелатонина на экспрессию генов в сердце мышей с помощью микрочипорой технологии // Докл. РАН. 2002. Т. 383. С. 276-281.

 

Анисимов С, В., Богилер К. Р., Хавинсон В, X., Анисимов В. Н. Изучение действия пептидов вилона и эпиталанона на экспрессию генов в сердце мыши с помощью технологии на основе микрочипов // Бюл. экспер. биол. мед. 2002а. Т. 133. С. 340- 347.

 

Безруков В. В., Чеботарев Д. Ф., Дупленко Ю. К. Киевский институт геронтологии: от основания до наших дней (к 40-летию института и 60-летию первой конференции по старению) // Клинич. геронтол. 1998. №3. С- 5-8.

 

Белозерова Л, М, Метод определения биологического возраста по работоспособности // Клинич. геронтол. 1998. № 2. С. 34-38.

Берштейн Л, М. Гормональный канцерогенез. СПб.: Наука, 2000. 199 с.

Берштейн Л. М., Алимова И. Н., Цырлина Е. В., Анисимов В. Н. Опухоли молочной железы у трансгенных мышей HER-2/neu отличаются низким содержанием эстрогенных рецепторов-альфа и отсутствием рецепторов прогестерона // Бюл. экспер. биол. мед. 2003. Т. 138. С. 680-682.

 

Белозерова Л. М, Онтогенетический метод определения биологического возраста человека // Успехи геронтол. 1999. Т. 3. С. 143-149.

Биология старения. Руководство. Л.: Наука, 1970.

Божков А. И. Низкокалорийная диета как модель увеличения продолжительности жизни и исследования механизмов старения // Успехи геронтол, 2001. Т. 7. С. 89-99.

 

Болдырев А. А. Карнозин. Биологическое значение и возможности применения в медицине. М.: Изд-во МГУ, 1998. 320 с.

Болотнова Т. В., Логинова И. В. Опыт изучения феномена долгожительства в г. Тюмени. Состояние здоровья долгожителей: влияние наследственных, эколого-климатических, социальных факторов на продолжительность жизни // Успехи геронтол. 2001. Т. 8. С. 82-88.

 

Бондарев И. Э., Бутюгов А. А., Смирнова Т. Д. и др. Индукция теломеразной активности и элонгация теломер пептидом эпиталон в соматических клетках человека//Мед. иммунология. 2003. Т. 5. С. 193-194.

 

Бондарснко И, Н., Лазарева В. С. Некоторые подходы к концепции социальной защиты пожилых людей на рубежу XXI века // Клинич. геронтол. 1998. №4. С. 3-8.

 

Бондаренко И. И., Лазарева В. С. Принципы ООН и перспективы организации социальной защиты пожилых граждан России // Успехи геронтол. 1999, Т. 3. С. 13-21.

 

Бурчинский С. Г., Дупленко Ю. К. Анализ современного состояния и перспектив развития геронтологических исследований (по результатам международной экспертизы) // Проблемы старения и долголетия. 1994. Т. 4. С. 275-283.

 

Ванюшин Б. Ф., Бердышев Г. Д. Молекулярно-генетические механизмы старения. М.: Медицина. 1977. 295 с.

Виленчик М, М. Молекулярные механизмы старения. М.: Наука, 1970. 168 с.

Вишневский А. Г. Воспроизводство населения и общество: История, современность, взгляд в будущее. М.: Финансы и статистика, 1982. 287 с.

Войтенко В. П., Токарь А, В., Полюхов А, М, Методика определения биологического возраста человека // Геронтология и гериатрия. 1984. Ежегодник. Биологический возраст. Наследственность и старение. Киев, 1984. С. 133-137.

 

Возрастная физиология: Руководство по физиологии. Л.: Наука, 1975.

Воробцова И. Е., Тимофеева Н, М, Богомазова А, Н., Семенов А, В, Возрастная зависимость частоты стабильных хромосомных аберраций, определяемых методом FISH, в лимфоцитах здоровых доноров и лиц, подвергшихся неконтролируемому облучению в малых дозах // Успехи геронтол. 1999. Т. 3-С. 88-93.

 

Гаврилов Л. А., Гаврилова Н. С. Биология продолжительности жизни. Количественные аспекты (2-е изд.). М.: Наука, 1991. 280 с.

Газиев А. И., Малахова Л, В., Фоменко Л. А. Медленная элиминация поврежденных оснований ДНК печени -облученных старых мышей // Докл. АН СССР. 1981.Т.257.С. 725-728.

 

Газиев А. И., Подлуцкий А. Я., Бредбери Р. Увеличение с возрастом частоты спонтанных и индуцированных -радиацией hprt-мутаций в лимфоцитах селезенки мышей //Докл. РАН. 1994. Т. 339. С. 276-278.

 

Газиев А. И., Ушакова Т. Е., Подлуцкий А, Я. и др. Диетические антиоксиданты увеличивают продолжительность жизни мышей, снижают частоту мутаций и увеличивают экспрессию защитных генов // Успехи геронтол, 1997. Т. 1. С. 80-84.

 

Гладышев Г. П. Термодинамика старения // Изв. РАН. Сер. биол. 1998. № 5. С. 533-543.

Гладышев Г. П. Термодинамическая теория старения выявляет причины старения и смерти с позиций общих законов природы // Успехи геронтол. 2001. Т. 7. С. 42-45.

 

Гладышев Г. П., Курникова И.В, Движущая сила эволюции живой материи и термодинамическая теория старения // Успехи геронтол. 1998. Т. 2. С. 49-58.

Голубев А. Г. Взаимная совместимость представлений о старении и продолжительности жизни, их механизмах и проявлениях на уровне организма и популяции, и их эволюция // Успехи геронтол. 1997. Т. 1. С. 25-33.

 

Голубев А. Г. Естественная история теломер // Успехи геронтол. 2001. Т. 7. С. 95-104.

Голубовский М. Д. Век генетики: эволюция идей и понятий. СПб.: Борей Арт, 2000. 262 с.

Губин Г. Д., Губин Д. Г., Комаров П. И. Старение в свете временной организации биологических систем // Успехи геронтол. 1998. Т. 2. С. 67-73.

Гусев В. А., Панченко Л. Ф. Современные концепции свободнорадикальной теории старения//Нейрохимия. 1997. Т. 14. С. 14-29.

Давыдовский И. В. Геронтология. М.: Медицина, 1966.

Демографический ежегодник России. 2002: Стат. сб. / Госкомстат России. М., 2002. 397 с.

Дильман В. М. Четыре модели медицины. М.: Медицина, 1987. 288 с.

Донцов В. И., Крутько В. И., Подколзин А. А. Фундаментальные механизмы геропрофилактики. М.: Биоииформсервис, 2002. 464 с.

Дубина Т. Л., Разумович А, Н. Введение в экспериментальную геронтологию. Минск: Наука и техника, 1975. 168 с.

Дупяенко Ю, К. Старение. Очерки развития проблемы. Л.: Наука, 1985. 192 с.

Дупяенко Ю. К, Бурчинсхий С, Г. Наукометрический анализ современных тенденций и приоритетов развития геронтологии // Пробл. старения и долголетия. 2000. Т. 9. С. 3-9.

 

Егоров Е. Е, Теломераза, старение, рак // Мол. биология. 1997. Т. 31. С. 16-24.

Зайнуллин В. Г., Москалев А. А, Радиоиндуцированное изменение продолжительности жизни лабораторных линий Drosopliila melanogasler II Генетика. 2001. Т. 37. С. 1304-1306.

 

Зайнуллин В. Г., Москалев А, А. Роль апоптоза в возрастных патологиях // Онтогенез. 2001а, Т. 32. №4. С. 245-251.

Зайнуллин В. Г., Москалев А. А. Роль генетической нестабильности в старении клетки //Генетика. 2000. Т. 36. С. 1013-1016.

Имянытов Е. N. Геронтологические аспекты молекулярной онкологии // Успехи геронтол. 1999. Т. 3. С. 111-115.

Ковина М. В., Хавинсон В. Х Стрекалов Д. Л. и др. Цитологические и молекулярные изменения при нетипичном случае ускоренного старения человека // Цитология. 2002. Т, 44. С. 930-935.

 

Колосова И. Г., Айдагулова С. В., Непомнящих Г, И. и др. Динамика структурных и функциональных изменений в митохондриях гепатоцитов крыс OXYS с ускоренным старением // Бюл. зкспер. биол. мед. 2001. Т. 132. С. 81-4-819.

 

Колыповер В. К. Свободнорадикальная теория старения: современное состояние и перспективы //Успехи геронтол. 1998. Т. 2. С. 37-42.

Комаров Ф. И., Анисимов В. И., Лихницкая И. И. Геронтология и гериатрия в России: состояние и перспективы // Клинич. геронтол. 1996. № 4. С. 3-8.

Коркушко О. В., Хавинсон В. X., Бутенко Г. М., Шатило В. Б. Пептидные препараты тимуса и эпифиза в профилактике ускоренного старения. СПб.: Наука, 2002. 202 с.

 

Котельников Г. П., Яковлев О. Г., Захарова Н. О. Геронтология и гериатрия: Учебник. М., Самара: Самарский Дом печати, 1997. 800 с.

Кременцова А, В., Конрадов А. А. Историческая динамика распределения продолжительности жизни человека //Успехи геронтол. 2001. Т. 8. С. 14-21.

Крутъко В. И., Подколзин А. А., Донцов В. И. Общие причины, механизмы и типы старения//Успехи геронтол. 1997. Т. I. С. 34-40.

Кудинов Ю. Г. Патологические последствия накопления конечных продуктов неферментативного гликозилирования при старении // Пробл. старения и долголетия. 1994. Т. 4. С. 434-451.

 

Ларионов Л. В. Рак и эндокринная система. Л.: Медицина, 1938.

Лежава Т. А. Функциональные особенности хромосом человека и старение// Успехи геронтол. 2001. Т. 8. С. 34-43.

Лихницкая И. И., Бахтияров Р.Ш. Академик 3. Г. Френкель и становление геронтологии в России // Успехи геронтол. 1997. Т. 1. С. 16--19.

Макругиин А. В. Как мог возникнуть механизм старческой инволюции // Успехи геронтол. 2001. Т. 7. С. 50-51.

Малыгина И. А., Костомарова И, В., Ганковская О. А, и др. Полиморфизм гена ангиотензинпревращающего фермента у больных ишемической болезнью сердца пожилого возраста// Клинич. геронтол. 1999. №4. С. 31-35.

 

Мануйлова Е. С, Лукаш Л. Л., Шапиро Н. И., Мутагены и опухолевый промотор//Генетика. 1985.Т.25.С. 1319-1326.

Мечников И, И, Эподы оптимизма. М.: Наука, 1988. 328 с.

Михайлова О. Н. Подготовка специалистов по гериатрии в Европе // Успехи геронтол. 2000. Т. 4. С. 165-170.

Михайлова О. Н., Забежинский М. А., Анисимов В. Н. Основные направления и перспективы международного сотрудничества в геронтологии. Роль Международной ассоциации геронтологии//Успехи геронтол. 2001. Т. 9. С. 7-16.

 

Михальскип А, И, Методы анализа гетерогенных структур и популяций. М.: Институт проблем управления им. В.А. Трапезникова РАН, 2002. 64 с.

Михальский А. И., Петровский А. М, Яшин А. И, Теория оценивания неоднородных популяций. М.: Наука, 1989. 120 с.

Михельсон В. М. Наследственное преждевременное старение человека // Клин, геронтол. 1996. №4. С. 4-10.

МоисеенкоА. Б., Берштейн Л. М. Инсулиноподобный фактор роста-1, связывающий его белок-3 и инсулин при колоректальном раке // Вопр. онкол. 2001. Т. 47. С. 383-387.

 

Морозов В. Г., Хавинсон В.Х. Пептидные биорегуляторы (25-летний опыт экспериментального и клинического изучения). СПб.: Наука, 1996. 74 с.

Москалев Ю. И. Отдаленные последствия воздействия ионизирующих излучений. М.: Медицина, 1991.464 с.

Мыльников С. В. Генетическая детерминация скорости старения в некоторых линиях Drosopltila melanogaster // Успехи геронтол. 1997. Т. 1. С. 50-56.

Напалков Н. П., Анисимов В. Н, Князев П. Г., Лихачев А. Я. Современные представления о механизмах канцерогенеза. Серия: обзоры по важнейшим проблемам медицины. Вып. 57. М.: ВНИИМИ. 1987. 84 с.

 

Население России. Девятый ежегодный демографический доклад // Под ред А. Г. Вишневского. М: Книжный дом "Университет", 2002.216 с.

Никитин Ю. П., Татаринова О. В. Демографические показатели долгожительства населения основных регионов Сибири и Дальнего Востока // Успехи геронтол. 1998. Т. 2. С. 33-36.

 

Никитин Ю. П., Татаринова О. В., Черных Н. И. Долгожительство в Сибири и на Дальнем Востоке: демографические и клинические аспекты. Новосибирск, 1999. 172 с.

 

Никитина В. Н. О взаимосвязи раннего старения организма с воздействием электромагнитных излучений //Клинич. геронтол. 1997. №3. С.14-18.

Новосельцев В. Н, Новосельцева Ж. А., Яшин А. И. Старение насекомых. I. Результаты экспериментальных исследований и основные модели // Успехи геронтол. 2000. Т. 4. С. 122-131.

 

Новосельцев В. Н, Новосельцева Ж. А., Яшин А. И. Старение насекомых. I. Гомеостатическая модель //Успехи геронтол. 2000а. Т. 4. С. 132-140.

Новосельцев В. Н, Новосельцева Ж. А., Яшин А. И. Математические модели истории жизни и баланса ресурсов // Успехи геронтол. 2001. Т. 7. С. 52-64.

Новосельцев В. Н., Новосельцева Ж. А., ЯшинА.И. Математическое моделирование в геронтологии - стратегические перспективы // Успехи геронтол. 2003. Т. 12. С. 149-165.

 

Обухова Л. К., Соловьева А. С., Жижина Г. П., Блюхтерова Н. В. Лонгитудинальное исследование возрастных и сезонных изменений продуктов эндогенного окисления ДНК у мышей // Успехи геронтол. 1997. Т. 1. С. 57-60.

 

Обухова Л. К., Эмануэль Н. М. Роль свободнорадикальных реакций окисления в молекулярных механизмах старения живых организмов // Успехи химии. 1983. Т. 52. С. 353-372.

 

Оловников А. М. Принцип маргинотомии в матричном синтезе полинуклеотидов// Докл. АН СССР. 1971. Т. 201. С. 1496-1499.

Оловников А. М, Внутриядерные ионные фонтаны как регуляторы деятельности генома: фонтанная гипотеза доминанты и некоторые эпигенетические эффекты // Мол. биол, 2000. Т. 35. С. 163-176.

 

Оловников А. М. Редусомная гипотеза старения и контроля биологического времени в индивидуальном развитии // Биохимия. 2003. Т. 68. С. 7-41.

Осипова Г. Ю., Анисимов В. Н. Канцерогенез, индуцированный неонатальным введением 5-бромо-2'-дезоксиуридина и последующим воздействием эстрадиола-бензоата, у самок мышей BALB/c // Вопр. онкол. 1992. Т. 38. С. 320-327.

 

Остроумова М. Н., Дильман В. М, Влияние экстракта эпифиза на порог чувствительности гипоталамуса к ингибирующему эффекту преднизолона // Вопр. онкол. 1972. №11. С. 53-57.

 

Пальцев М, А, Современные подходы к изучению патогенеза болезней // Вестн. РАМН. 1999. №9. С. 22-25.

Пальцев М А. Демура С. А., Коган Е. A. et al. Роль Всl-2, Вах и Ваk в спонтанном апоптозе и пролиферации в нейроэндокринных опухолях легких: иммуногистохимическое исследование // Бюл. экспер. биол. мед. 2000. Т. 130. С. 697-700.

 

Пархон К. И. Возрастная биология. Бухарест: Меридианы, 1960. 348 с.

Пирожков С, И., Сафарова Г. Л, Тенденции старения населений России и Украины: демографические аспекты // Успехи геронтол. 2000. Т. 4. С. 14-20.

Пирожков С, И., Сафарова Г. Л. Демографические прогнозы для России и Украины//Успехи геронтол. 2001. Т. 7. С. 26-36.

Плачинда Ю. И., Нягу А. И. Способ определения жизнеспособности и прогнозирования предстоящей продолжительности человека // Пробл. старения и долголетия. 2002. Т. 11. С. 133-139.

 

Плешакова О. В., Расскаъова Е, А., Сухарев С. А. и др. Переваривание окислительно модифицированных белков протеолитическими ферментами из нейтрофилов мышей разного возраста//Докл. РАН. 2000. Т. 374. С. 189-191.

 

Пожилые люди в Российской Федерации: положение, проблемы, перспективы. Национальный доклад. М.: Права человека, 2002. 56 с.

Полякова В. О., Кветной И. М., Хавинсон Б. X. и др. Тимус и старение // Успехи геронтол. 2001. Т. 8. С. 50-57.

Попович И. Г., Войтенков Б. О., Анисимов В. И. и др. Влияние пептида дельта-сна на продолжительность жизни и развитие спонтанных опухолей у мышей // Докл. РАН. 2003. Т. 388. С. 2&-30.

 

Потапенко А. И., Акифъев А. П. На пути поиска программы и инициального субстрата старения // Успехи геронтол. 1999. Т. 3. С. 68-80.

Потапенко А. И., Рудаковская Е. Г., Акифьее А. П. Экспериментальный подход к анализу клеточного и молекулярного субстрата старения: влияние 5-бромо-2'-дезоксиуридина на продолжительность жизни и поведение D. mela-nogasterli Онтогенез. 1998. Т. 28. С. 680-686.

 

Прудчеико И. А., Михалева И. И. Проблема эндогенности пептида дельта-сна // Успехи совр. биол. 1994. Т. 114. С. 728-740.

Пушкова Э. С. Современные возможные направления развития социальной геронтологии // Успехи геронтол. 2001. Вып. 7. С. 110-114.

Пушкова Э. С, Ленская Л. В. Долгожительство в Санкт-Петербурге // Успехи геронтол. J999. Т. 3. С. 22-26.

Пушкова Э. С, Клемина Л. В., Иванова Л.В. Долгожительство: сравнительный анализ состояния вопроса в Санкт-Петербурге и штате Айова, США // Клинич. геронтол. J997. № 3. С. 53-59.

 

Ревской С. Ю. Онкосупрессор bcl-2 как возможный посредник между генотоксическим стрессом и нарушением гормонального гомеостаза // Вопр. онкол. 200J. Т. 47. С. 224-229.

 

Розенфельд С. В. Спонтанный мутагенез у мышей разных линий при старении //Успехи геронтол. 2001. Т. 8. С. 44-49.

Розенфельд С В., Того Е, Ф., Михеев В. С. и др. Влияние эпиталона на частоту хромосомных повреждений у мышей SAM с ускоренным старением // Бюл. экспер. биол. мед. 2002. Т. 133. С. 320-322.

 

Розоноэр Л. И, Седых Е Л. Об эволюционных механизмах самовоспроизводящихся систем // Автоматика и телемеханика. 1979. №2. С. 110-119; Ns3. С. 119-130.

Романенко В. И. Мелатонин как возможный эндогенный лейкозогенный (бластомогенный) агент //Гематол. трансфузиол. J983. №2. С. 47-50.

Романюха А. А., Яшин А. И. Математическая модель возрастных изменений в популяции периферических Т-лимфоцитов // Успехи геронтол. 2001. Т. 8. С. 58-69.

 

Рыжман Н, Н., Андрианов В. П. Влияние социально-гигиенических условий службы и быта на биологический возраст офицерского состава Северного флота // Современные проблемы общей и военно-морской терапии. Труды ВМА. 2001. Т. 252. С. 141-151.

 

Сафарова Г, Л. Демографические аспекты старения населения России // Успехи геронтологии. 1997. Т. 2. С. 20-ТА.

Сафарова Г. Л. Старение населения Санкт-Петербурга: современное состояние и среднесрочные прогнозы//Успехи геронтол. 2002. Т. 10. С. 18-28.

Сидоренко А., Эндрюс Г. ООН возглавляет Программу исследований старения в XXI столетии // Успехи геронтол. 2000. Т. 4. С. 7-13.

Скулачее В. П. Старение организма - особая биологическая функция, а не результат поломки сложной живой системы: биохимическое обоснование концепции Вейсмана // Биохимия. 1997. Т, 62. С. 1369-1399.

 

Смирнова А. И., Вершинина Е. А., Мыльников С. В. Изучение вклада трех больших хромосом дрозофилы в детерминацию динамики смертности и интенсивности перекисного окисления липидов // Успехи геронтол. 2000. Т. 4. С. 50-54.

 

Соловьев М. В, О возможной роли хаотического поведения системы генной регуляции в старении организма//Успехи геронтол. 2001. Т. 8. С. 27-33.

Спивак И. М., Смирнова Н. И., Плескан И. М., Кольман А. Влияние иммортализации на репаративный потенциал клеток при прогерии // Успехи геронтол. 1999. Т. 3. С 94-102.

 

Стрелер Б. Время, клетки, старение. М.: ИЛ, 1966.

Стуков А. И. Элеутерококк и спонтанный лейкоз у мышей // Вопр. онкол. 1965. №12. С. 64-65.

Того А. В., Григорьев М. Ю., Суспицын Е. И. и др. Распределение аллелей онкогена L-MYC у лиц с онкологической предрасположенностью и онкологической толерантностью // Клинич. геронтол. 1999. № 4. С. 36-42.

 

Уманский С. Р. Генетическая программа клеточной гибели: гипотеза и некоторые приложения (трансформация, канцерогенез, старение) // Успехи соврем, биол. 1982. Т. 93. С 139-148.

 

Урланис Б.Ц. Эволюция продолжительности жизни. М., 1978.

Урываева И. В., Маршак Т. Л., Захидов С. Т. и др. Микроядрышковые аберрации накапливаются с возрастом в клетках печени мышей линии SAM с ускоренным старением //Докл. РАН. 1999. Т. 368. С. 703-705.

 

Фрейдлин И. С. Иммунная система и ее дефекты: Руководство для врачей. СПб.: НТФФ Полисан, 1998. 113 с.

Фролькис В. В. Регулирование, приспособление и старение. Л.: Наука, 1970.432 с.

Фролькис В. В., Мурадян X. К. Старение. Эволюция и продление жизни. Киев: Наукова думка, 1992. 336 с.

Фролькис В. В.. Мурадян X. К. Экспериментальные пути продления жизни. Л.: Наука, 1988. 248 с.

Хавинсон В. X., Анисицов В. И. Пептидная биорегуляция и старение. СЩ5.: Наука, 2003. 223 с.

Хавинсон В. X., Морозов В. Г. Геролротекторная эффективность тималина и эпиталамина // Успехи геронтол. 2002. Т. 10. С. 74-84.

Хавинсон В. X., Морозов В. Г., Соловьева Д. В., Малцнцн В. В. Применение эпиталамина для профилактики и лечения генетически детерминированной возрастной патологии//Успехи геронтол. 1998. Т. 2. С. 103-106.

 

Хавинсон В. X., Соловьева Д. В., Стрекалов Д. Л. и др. Анализ распределения в российской популяции некоторых генетических маркеров, ассоциированных с мультифакториальной патологией среднего и пожилого возраста // Мед. акад. журн. 2002. Т. 2, № 2. С. 56-66.

 

Халявкин А. В. Взаимодействие "организм-среда" и причины старения // Успехи геронтол. 1998. Т. 2. С. 43-48.

Хансон К. П. Роль апоптоза в старении и возрастной патологии // Успехи геронтол. 1999. Т. 3. С. 103-110.

Хелимскнй А. М. К вопросу о возрастных изменениях шишковидной железы// Пробл. эндокринол. 1958. № 2. С. 96-100.

ХороишттаЛ. П. Голодание в детстве как причина болезней в старости (на примере малолетних жителей блокированного Ленинграда). СПб.: Издательский дом СПбМАПО, 2002. 188 с.

 

Хохлов А. И. Пролиферация и старение. Общие проблемы физико-химической биологии (Итоги науки и техники ВИНИТИ АН СССР). М., 1988. Т. 9. С. 5-174.

Шабалин А. В., Никитин Ю. П., Рагино Ю. И. и др. Липиды крови, окислительная резистентность липопротеинов низкой плотности, концентрация жирорастворимых антиоксндантов у людей старческого возраста и долгожителей г. Новосибирска//Успехи геронтол. 2002. Т. 10. С. 64-68.

 

Черкес Л. А., Аптекарь С. Г.. Волгарее М. Н. Опухоли печени, вызванные селеном // Бюл. экспер. биол. мед. 1962. Т. 53, № 3. С. 78-83.

Эмануэль И. М. Некоторые молекулярные механизмы и перспективы профилактики старения//Изв. АН СССР. Сер. Биол. 1975. №4. С. 785-794.

Эндрюс Г. Р. Стратегические направления работы Международной ассоциации геронтологии // Успехи геронтол, 2001. Т. 8. С. 7-13.

Юнева М, О., Гусева И, В., Болдырев А. А. Линия мышей SAM как модель процесса старения, вызываемого активными формами кислорода// Успехи геронтол. 2000. Т. 4. С. 147-152.

 

Янтарная кислота в медицине, пищевой промышленности, сельском хозяйстве / Под ред. М. Н. Кондрашовой, Ю.Г.Каминского, Е. И. Маевского. Пущино: ИТЭБФ РАН, 1997. 300 с.

 

Яршин А, А. Основы иммунологии, М.: Медицина, 1999. 607 с.

Abbott M. N., Abbey N., Boiling D. R., Murphy E. A. The familial component in longevity. A study of the offsprings of nonagenarians. 3. Intrafamilial studies // Amer. J. Med. Genet. 1978. Vol. 2. P. 105-120.

 

Adams J. M., Cory S. The Bcl-2 protein family: arbiters of cell survival // Science. 1998. Vol. 281. P. 1322-1326.

Agarwal S., Sohal R. S. Aging and protein oxidative damage // Mech. Ageing Dev. 1994. Vol. 75. P. 11-19.

Aigaki Т., Seong K., Matsuo T. Longevity determination genes in Drosophila melanogaster // Mech. Ageing Dev. 2002. Vol. 123. P. 1531-1541.

Alexander J. Use of transgenic mice in identifying chemopreventive agents // Toxicol. Lett. 2000. Vol. 112/113. P. 507-512.

Alexandrov S. N. Late Radiation Pathology of Mammals. Fortschritte der Onkologie. Bd 6, Berlin: Akademik-Verlag. 1982.

Alexandrov V. A., Anisimov V. N., Belous N. M, et at. The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration ofbufortnintorats //Carcinogenesis. 1980. Vol. l.P. 975-978.

 

Alexandrov V. A. Popovich I. C., Anisimov V. N., Napatkov N. P. Influence of hormonal disturbances on transplacental and rnultigeneration carcinogenesis // Eds N. P. Napalkov, J. M. Rice, L. Tomatis, H. Yamasaki. Perinatal and Multigeneration Carcinogenesis. IARC Sci Publ N 96. Lyon: IARC, 1989. P. 35-50.

 

Allay E., Veigl M., Gerson S. L, Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 rnethylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea // Oncogene. 1999. Vol. 18. P. 3783-3787.

 

Alpatov V. Geriatrics in the Soviet Union //Geriatrics. 1965. Vol. 20. P. 348-350.

Ames B, N. Endogenous DNA damage as related to cancer and aging // Mutat. Res. 1989. Vol. 214. P. 41-46.

Ames B. N., Shigenaga M. K., Hogen Т. М. Oxidants, antioxidants, and the degenerative diseasesof aging//Proc. Natl. Acad. Sci. USA. 1993. Vol.90. P. 7915-7921.

 

Andersen J. K. Genetically engineered mice and their use in aging research // Mol. Biotechnol. 2001. Vol. 19. P. 45-57.

Andrechek E. R, Hardy W. R., Siegel P. M. et al. Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis // Proc. Natl. Acad. Sci. USA. 2000. Vol. 97. P. 3444-3449.

 

Andrews G. R, Sidorenko A., Andrianova L F., Anisimov V. N. etal The United Nation research agenda on ageing for the 21st cenmry // Успехи геронтол. 2001. Т. 7, С. 7-25.

 

Anisimov S. V., Boheler К. R. Aging-associated changes in cardiac gene expression: Jarge scale transcriptome analysis // Успехи геронтол. 2003. Т. 11. С. 67-75.

 

Anisimov S. V., Tarasov К. V., Stern M. D. et al. A quantitative and validated SAGE transcriptome reference for adult mouse heart // Genomics. 2002. Vol. 80. P. 213-222.

 

Anisimov S. V., Volkova M. V., Lenskaya L V. ei at. Age-associated accumulation of the Apolipoprotein C-lll gene T-455C polymorphism С allele in a Russian population// J. Gerontol. A Biol. Sci. Med. Sri, 2001. Vol. 56A. P. 827-832.

 

Anisimov V. N. Carcinogenesis and aging // Adv. Cancer Res. 1983. Vol. 40. P. 365-424.

Anisimov V. N. Carciriogenesis and Aging. Vol. 1, 2. Boca RaVoru CRC Press, 1987. 165. 148 p.

Anisimov V. N. Effect of age on dose-response relationship in carcinogenesis induced by single administration of N-nitrosomethylurea in female rats // J. Cancer Res. Clin. Oncol. 1988. Vol. 114. P. 628-635.

 

Anisimov V. N. Age and dose-dependent carcinogenic effects of N-nitrosomethylurea administered intraperitoneally in a single dose to young and adult female mice //J. Cancer Res. Clin. Oncol. 1993. Vol. 119. P. 657-664.

 

Anisimov V. N. The sole DNA damage induced by bromodeoxyuridine is sufficient for initiation of both aging and cancer in vivo // Ann. N.Y. Acad. Sqj, (994. Vol. 719. P. 494-501.

 

Anisimov V. N. Carcinogenesis induced by neonatal exposure to various doses of 5-bromo-2'-deoxyuridine in tats // Cancer Lett. 1995. Vol. 91. P. 63-171.

 

Anisimov V. N. Effect of aging and interval between primary and secondary treatment in carcinogenesis induced by neonatal exposure to 5-bromodeoxyuridine and subsequent administration of N-nitrosomethylurea in rats // Mutat. Res. 1995a. Vol.316. P. 173-187.

 

Anisimov V. N. Age as a risk factor in multistage carcinogenesis // Comprehensive Geriatric Oncology / Eds. L. Balducci, G- H. Lyman, W. B, Ershler. Amsterdam: Harwood Acad. Publ. 1998. P.157-178.

 

Anisimov V. N. Ageing and the mechanisms of carcinogenesis: some practical implications//J. Exp. Clin. Cancer Res. 1998a. Vol. 17. P. 264-268.

Anisimov V. N. Experimental research on ageing in Russia // Exp. Gerontol. 2001. Vol. 26. P. 935-946.

Anisimov V. N. Life span extension and cancer risk: myths and reality // Exp. Gerontol. 2001a. Vol. 36. P. 1101-1136.

Anisimov V. N. Melatonin and colon carcinogenesis // The Pineal Gland and Cancer / Eds C. Bartsch, H. Bartsch, D. Blask et al. Berlin, Heidelberg: Springer-Verlag. 2001b. P. 240-258.

 

Anisimov V. N. Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis // Mech. Ageing Dev. 2001c. Vol. 122. P. 121-125.

 

Anisimov V. N. The light-dark regimen and cancer development // Neuro-endocrinoi. Lett. 2002. Vol. 23 (Suppl. 2). P. 28-36.

Anisimw V. N. The relationship between aging and carcinogenesis: a critical appraisal // Crit. Rev. Oncol. Hematol. 2003. Vol. 45. P. 277-304.

Anisimov V. N. The role of pineal gland in breast cancer development // Crit. Rev. Oncol. Hematol. 2003. Vol. 46. P. 221-234.

Anisimov V. N., Gvardina О. E. N-nitrosomethylurea-induced earcinogenesis in (he progeny of male rats of different ages //Mutat. Res. 1995. Vol. 316. P. 139-145.

 

Anisimov V. N, Lazebnik L. B. Current status and perspectives of gerontology in Russia // Aging. Clin. Exp. Res. 2000. Vol. 12. P. 53-58.

Anisimov V. N., Osipova G. Y. Effect of neonatal exposure to 5-bromo-2'-deoxyuri-dineon life span, estrus function and tumor development in rats - an argument in favor of the mutation theory of aging?// Mutat. Res. 1992. Vol. 275. P. 97-110.

 

Anisimov V. N., Osipova G. Y. Two-step earcinogenesis induced by neonatal exposure to 5-bromo-2'-deoxyundine and subsequent administration of urethan in BALB/c mice // Cancer Lett. 1992a. Vol. 64. P. 75-82.

 

Anisimov V. N., Osipova G. Y. Carcinogenesis induced by combined neonatal exposure to 5-bromo-2'deoxyuridine and subsequent total-body X-ray irradiation in rats//CancerLett.1993. Vol. 70. P. 81-90.

 

Anisimov V. N., Osipova G. Yu. Life span reduction and carcinogenesis in the progeny of rats exposed neonatally to 5-bromo-2'-deoxyuridine // Mutat. Res. 1993a. Vol. 295. P. 113-123.

 

Anisimov V. N., Khavinson V.Kh., Morozov V. G. Carcinogenesis and aging. IV. Effect of low-molecular weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice // Mech. Ageing Dev. 1982. Vol. 19. P. 245-258.

 

Anisimov V. N., Zhukovskaya N. V., LoktionovA. S. et al. Influence of host age on lung colony forming capacity of injected rat rhabdomyosarcorna cells // Cancer Lett. 1988. Vol. 40. P. 77-82.

 

Anisimov V. N., LoktionovA. S., Khavinson V. K., Morozov V. G. Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age // Mech. Ageing Dev. 1989. Vol. 49. P. 245-257.

 

Anisimov V. N., Bondarenko L. A., Khavinson V.Kh. The pineal peptides: interaction with indoles and the role in aging and cancer // Neuroendocrinology: New Frontiers / Eds D. Gupta, H. A. Wollmann, M. B. Ranke. London: Tubingen: Brain Res. Promotion. 1990. P. 317-325.

 

Anisimov V. N., Sheiko E. V., Zhukovskaya N. V. Effect of age on development of tumours in the intrasplenic ovarian grafts in ovariectomized rats // J. Cancer Res. Clin. Oncol. 1992. Vol. 119. P. 111-116.

 

Anisimov V. N., Birnbaum L. S., Butenko G. M. et at. Principles for Evaluating Chemical Effects on the Aged Population. Environmental Health Criteria 144. Geneva. WHO. 1993. 159 p.

 

Anisimov V. N., Khavinson V. Kh., Morozov V. G. Twenty years of study on effects of pineal peptide preparation: Epithalamin in experimental gerontology and oncology//Ann. N. Y. Acad. Sci. 1994. Vol. 719. P. 483-493.

 

Anisimov V. К, Zhukovskaya N. V., LoktionovA. S. et at. Host and donor age dependency of colony forming capacity of lung-affine rat rhabdomyosarcorna RA-2 cells. Abstr of the Int. Conf. on Tumor Micro environment: Progression, Therapy and Prevention. Tiberias, Israel, 1995. P. 6.

 

Anisimov V. N., MylnikovS. V., Oparina T. I., Khavinson V.Kh. Effect of mela-tonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drvsophiia melanogasterft Mech. Ageing Dev, 1997. Vol. 97. P. 81-91.

 

Anisimov V. N., Popovich I. G., Zabezhinski M. A. Melatonin and colon carcino-genesis: I. Inhibitory effects of melatonin on development of intestinal tumors induced by l^-dimethylhydrazineinrats//Carcinogenesis. 1997a. Vol. 18. P. 1549-1553.

 

Anisimov V. JV., MylnikovS, V., Khavinson V.Kh. Pineal peptide preparation epj-thalamjn increases the lifespan of fruit flies, mice and rats // Mech. Ageing Dev. 1998. Vol. 103. С 123-132.

 

Anisimov V. N., Zabezhinski M. A., Popovich I. G. Prevention of spontaneous and chemically-induced carcinogenesis using activated carbon fiber adsorbent. 1. Affect of the activated carbon fiber adsorbent 'Aqualen' on spontaneous carcinogenesis and life-span in mice//Cancer Lett. 1998a. Vol. 126. P. 23-28.

 

Anisimov V. N., Khavinson V. K., Morozov V. G. Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats// Biogerontology. 2000. Vol. 1. P. 55-59.

 

Anisimov V. N., Zabezhinski M, A., Popovich J. G. et al. Inhibitory effect of melatonin on 7,12-dimethylbenz[a] anthracene-induced carcinogenesis of the uterine cervix and vagina in mice and mutagenesis in vitro // Cancer Lett. 2000a. Vol. 156. P. 199-205.

 

Anisimov V. JV., Arutjunyan A. V., Khavinson V. Kh. Effect of pineal peptide preparation Epithalamin on free radical processes in animals and humans // Neuroen-docr. Lett. 2001. Vol. 22. P. 9-18.

 

Anisimov V. N., Khavinson V. K., Mikhalski A. I., Yashin A. I. Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice//Mech. Ageing Dev. 2001a. Vol. 122. P. 41-68.

 

Anisimov V. N., ZavarzUtafJ. Y., Zabezhinski M. A. et at. Melatonin increases both life span and tumor incidence in female CBA mice // J. Gerontol. Biol. Sci. 2001b. Vol. 56A. P. B311-B323.

 

Anisimov V. N., Khavinson V.Kh., Popovich L C, Zabezhinski M. A. Inhibitory effect of peptide Epitalon in colon carcinogenesis induced by 1,2-dimethylhydrazinc in rats // Cancer Lett. 2002. Vol. 183. P. 1-8.

 

Anisimov V. N., Alimova 1. N., Baturin D. A. et at Dose-dependent effect of melatonin on life span and speontaneous tumor incidence in female SHR mice // Exp. Gerontol. 2003. Vol. 38. P. 449-461.

 

Anisimov V. JV., Alimova 1. JV., Baturin D. A. et at The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER-2/neu transgenic mice // Int. J. Cancer. 2003a. Vol. 103. P. 300-305.

 

Apfeld J., Kenyon C. Cell nonauionomy of С elegans daf-2 function in the regulation of diapause and life span //Cell. 1998. Vol. 95. P. 199-210.

Aragona M., Maisano R., Panetta S. et at. Telomere length maintenance in aging and carcinogenesis //Int. J. Oncol. 2000. Vol. 17. P. 981-989.

Anno О., Kimmel M., Webb С. F. Mathematical modeling of the loss of te-lomereseqences//J.Theor. Biol.1995. Vol. J77. P. 45-57.

Arking R. Biology of Aging: Observations and Principles. Englewood Gliffs, N. J.: Prentce Hall, Inc., 1991.

Arking R., Force A. G., Dugas S. P. et al. Factors contributing to the plasticity of the extended longevity phenotypes of Drosophila // Exp, Cerontol. 1996. Vol. 3t, P. 623-643.

 

Arking D. E, Krebsova A., MacekS. M. etal. Association of human aging with a functional variant of klotho//Proc. Natl. Acad. Sci. USA. 2002. Vol. 99. P. 856-861.

 

Artandi S. ?., Chang S., Lee L. et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice // Nature, 2000. Vol. 40. P. 641-645.

 

Artandi S. ?., DePinlio R. A. Mice without telomerase: what can they teach us about human cancer? // Nature Medicine. 2000. Vol. 6. P. 852-855.

Asa S. L, Kovacs K., Stefaneanu L. et at. Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone // Pros. Soc. Exp. Biol. Med. 1990. Vol. 193. P. 323-325.

 

Asada Т., Yamagata Z, Kinoshita T. et at Prevalence of dementia and distribution of ApoE alleies in Japanese centenarians: an almost-complete survey in Yama-nashi prefecture, Japan//J. Amer. Geriatr. Soc. 1996. Vol. 44. P. 151-155.

 

Aston A., Vmbilescu A., Dotnilescu C. et al. Long-term treatment with procaine (gerovital H3) in albino rtas//J. Cerontol. 1965. Vol.20. P. 1-8.

Atardi L D., Jacks T. The role of p53 in tumour suppression: lessons from mouse models//Cell. Mol. Life Sci. 1999. Vol. 55. P. 48-63.

Awariani K. A., Cheung A. P. Metformin and polycystic ovary syndrome: a literature review // J. Obstet. Gynecol. Can. 2002. Vol. 24. P. 393-401.

Bab'tchH. Butylated hydroxytoluene (BHT): a review // Environ. Res. 1982. Vol.29. P. 1-29.

Backman V., Wallace M. В., Perelman L T, et al. Detection of preinvasive cancer cells // Nature. 2000. Vol. 406. P. 35-36.

BakaevV, V. Effect of 1-butylbiguanide hydrochloride on the longevity in the nzrnatoda Caenorhabditis etegans ff Biogeixsniology. 2002. Vol. 3. Suppl. 1. P. 23-24.

 

Bakaev V. V., Efremov A. V., Anisitnov V. JV. An attempt to slow aging in С ele-gans. 8. Melatonin reduces life span of С elegans it The Worm Breeder Gazette. 1997. Vol. 15, NIP. 36.

 

Baker G. Т., Sprott R.L Biornarkers of aging // Exp. Cerontol. 1988. Vol. 23. P. 223-239.

Balmain A., GrayJ., Ponder B. The genetcs and genomics of cancer // Nature Genet. 2003. Vol. 33. P. 238-244.

Baratwvskaya S., KuSnov S., Fomiclteva E. et at Age as a risk factor for myo-cardial infarction in Leiden mutation carriers // Mol. Genet. Metab. 1998. Vol. 64. P. 155-157.

 

Batja G. Endogenous oxidative stress: relationship to aging, longevity and caloric restriction // Ageing Res. Rev. 2002. Vol. 1. P. 397-411.

Barlow C., Hirotsune S., Paytor R. et al. Atm-deficient mice: a paradigm of ataxia telangiectasia // Cell. 1996. Vol. 86. P. 159-171.

Barrett J, С, Tsutstd Т., Ts'o P. О. Р. Neoplastic transformation induced by a direct perturbation of DNA // Nature. 1978. Vol. 274. P. 229-232.

Bartke A., Turyn D. Mechanisms of prolonged longevity: mutants, knock-outs, and caloric restriction//J. Anti-Aging Med. 2001. Vol.4. P. 197-203.

Bartke A., Brown-Borg H., Mattison J. et al. Prolonged longevity of hypopitui-tary mice// Exp. Gerontol. 2001. Vol. 36. P. 21-28.

Bartke A., CoschiganoK., KopchickJ. et ai. Genes that prolong life: relationships of growth hormone and growth to aging and life span // J. Gerontol. Biol. Sci. 200{. Vol. 56A. P. B340-B349.

 

BartkeA., Chandrashekar V., DominiciF. et at Insulin-like growth factor 1 (IGF-1) and aging: controverses and new insights // Biogerontology. 2003. Vol. 4. P. 1-8.

 

Bartsch C, Bartsch H., BUtsk D. E. et al. (eds). The Pineal Gland and Cancer. Neuroimmunoendocrine Mechanisms in Malignancy. Berlin: Springer, 2001. 578 p.

 

Baserga R. L. Cell dvision and the cell cycle //Handbook of the Biology of Aging/ EdsC.E. Finch, L. Hayflick, N. Y.: Van Nostrand Reinholdd, 1977. P. 101-121.

 

Bashkireva A. S., Artamonova V. G Premature ageing diagnosis and prevention in occupational and environmental health//Adv. Gerontol. 2000. Vol. 5. P. 17-18.

 

Battahra M. St. J., Spadling J. W., Szczesniak C. J. et al. Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mice // Carcinogenesis. 2001. Vol. 22. P. 651-659.

 

Baturin D. A., Atimoval. N., Anisimov V. N. et at The effect of light regimen and rnelatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a down regulation of HER-2/neu gene expression // Neu-roendocrinol Lett. 2001. Vol. 22. P. 439-^45.

 

Bellamy D. Long-term action of prednisolone phosphate on a strain of shortlived mice // Exp. Gerontol. 1968. Vol. 3. P. 327-333.

Benhamcu S., Sarasin A. Variability in nucleotide excision repair and cancer risk: a review // Mutat. Res. 2000. Vol. 462. P. 149-158.

Berger N.A., Sim J. L, Catiiw D. M., BergerS.J. Poly(ADP-ribose) mediates the suicide response to massive DNA damage: studies in normal and DNA repair defective cells / Eds M. Miva, O. Hayashi, S. Shall et al. ADP-ribolysation, DNA Repair, and Cancer//Jpn. Sci. Soc. Press, Tokyo. 1997. P. 219-226.

 

Berstein L. M. Macrosomy, obesity and canter. New York: Nova Sci. Publ. 1997.195 р.

Bernstein C, Bernstein И. Aging, Sex, and DNA Repair. San Diego: Acad. Press, Inc., 1991.

Bielas J. H., Heddle J. A. Proliferation is necessary for both repair and mutation in transgenic mouse cells // Proc Natl. Acad. Sci. USA. 2000. Vol. 97. P. 11391-11396.

 

B'Utles A. #., Fulder S. J., Grant E. C, Nichotts M. R. The effect of gingseng on lifespan and stress responses in mice//Gerontology. 1979. Vol. 25. P. 125^-131.

 

Blackett A. D., Hall D. A. The effects of vitamin Eon mouse fitness and survival // Gerontology. 1981. Vol. 27. P. 133-139.

Blackwell В., Bucc'tT. J., Hart R. W., Turturro A. Longevity, body weight, and neoplasia in ad libitum-ied and diet restricted C57BL6 mice fed N1H-31 орел formula diet // Toxkol Pathol. 1996. Vol. 23. P. 570-582.

 

Blasco M.A. Telomerase beyond telomeres // Nature Rev. Cancer. 2002. Vol. 2. P. 1-7.

Blasco M. A., Lee H. W-, Hande M. P. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA // CelJ. 1997. Vol. 91. P. 25-34.

 

Blntmer F. /?., PlunketG., BhchC.A. et al The complete sequence of Јs-cftericftia coti K-\2 //Science. 1997. Vol. 277. P. 1453-J474

Btuher M., Kahn В. В., Kahn С R. Extended longevity in mice lacking the insulin receptor in adipose tissue // Science. 2003. Vol. 299. P: 572-574.

Bodnar A. G, Ouellette M., FroikisM, et al. Extension of life span by introduction of telomerase into normal human cells//Sciences. J998. Vol. 279. P. 349-352,

 

Bodyak N. ?>., Nekhaeva E., Wei J. У., Khrapko K. Quant it at ion and sequencing of somatic deleted rntDNA in single cells: evidence for partially duplicated mtDNA in aged human tissues //Human Mol. Genetics. 2001. Vol. 10. P. 17-24.

 

Boerrigter M. E.T. J., Wei J. K, Vijg J. Induction and repir of benzo[a]pyrene-DNA adduces in C57BL/6 and BALB/c mice: association with aging and longevity // Mech. Ageing Dev. 1995. Vol. 82. P. 3150.

 

Bohr V. A. Human premature aging syndromes and genomic instability // Mech. Ageing Dev. 2002. Vol. 123. P. 987-993.

Bonafe M., Barbieri M., Marchegiani F. et al. Polymorphic variants of insulin-like growth factor-! (ICF-) receptor and phosphoinositide 3-kinase genes affect IGF-1 plasma levels and human logevity: cues for an evolutionary conserved mechanism of life span control // J. Clin. Endocrinol. Metab. 2003. VoJ. 88. P. 3299-3304.

 

Bonafe M., Cardelli M., Marchegiani F. et aL Increase of homozygosky in centenarians revealed by a new inter-Afa PCR technique // Exp. Gerontol. 2000. Vol. 36. P. 1063-1073.

 

Bordin P., Da Gol P. G., Peruzz.o P. et at. Causes of death and clinical diagnostic error in extreme aged hosptalized people: a retrospective clinical-necropsy survey // J. Gerontol. Med. Sci. 1999. 54A. P. M554-M559.

 

Boveri T. H. ZurFtagederEntstehung malingner Tumoren. Jena: Fischer. 1914.

Brainard G. C, Kaver R., Kheifets L. t. The relationship between electromagnetic field and light exposure to melatonin and breast cancer risk: a review of the relevant literature Hi. Pineal Res. 1999. Vol. 26. P. 65-100.

 

Bringold F., Serrano M. Tumor suppressors and oncogenes in cellular senescence // Exp. Gerontol. 2000. Vol. 35. P. 317-329.

Brinster R, L, Chen H. K, Trumbauer M. E. et al. Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs // Proc. Natl. Acad. Sci. USA. 1985. Vol. 82. P. 4438-4442.

 

Brizztsr K.R. Neuronaging and neural pathology // In*. Relations Between Normal Aging and Disease / Ed. A. H. Johnson. New York: Raven Press, 1985. P. 191-224.

 

BrodyJ. A., Schneider E.L. Diseases and disorders of aging: an hypothesis // }. Chronic Dis. 1986. Vol. 39. P. 871-876.

Brown K. S., Forbes W. F. A mathematical model of aging processes // J. Gerontol. 1974 Vol. 29. P. 46-51.

Brown W. T. Genetic diseases of premature aging as tnodels of senescence // Annu. Rev. Gerontol. Geriatr. 1990. Vol. 10. P. 23-42.

Brown-Borg H. М., Borg К. Е., Meliska С. J., Bartke A. Dwarf mice and the aging process // Nature. 1996. Vol. 384. P. 33.

Brvwn-Borg H. M., Rakoczy S, G Catalase expression in delayed and premature aging mouse models// Exp. Gerontol. 2000. Vol. 35. P. 199-212.

Bruskov V. I., Malakhova L. V., MasalimovZ. K., Chernikov A. V. Heat-induced formationof reactive oxygenspecies and 8-oxoguanine, a biomarker of damage to DNA // Nucleic Acvids Res. 2002. Vol. 30. P. 1354-1363.

 

Bryan T. M., Englezou A., Gupta J. et al. Telomere elongation in immortal human cells without detectable telomerase activity // EMBO J. 1995. Vol. 14. p. 4240-4248.

 

Buettner V. L, Nish'tno H., Haavik J. et at. Spontaneous mutation frequencies and spectra in p53 (+/+) and p53(-/-) mic": a test of the 'guardian of the genome' hypothesis in th Big Blue transgenic mouse mutation detection system// Mutat. Res. 1997. Vol. 379. P. 13-20.

 

Burkle A. In memoriam Bernard Strchlcr - genomic instability in ageing: a persistent challenge // Mech. Ageing Dev. 2002. Vol. J. P. 899-906.

Butler R. N., AustadS. N., Barztlai N. et aL Longevity genes: from primitive organisms to humans //J. Gerontol. Biol. Sci. 2003. Vol. 58A. P. 581-584.

Butkr R.N., FosselM., Harmon M. et at. Is there an antiaging medicine? // J. Gerontol. Biol. Sci. 2002. Vol. 57A. P. B333-B338.

Butov A. A., VolkovM. A., Anisimov V. N.etaL A model of accelerated aging induced by 5-bromodeoxyuridine// Biogerontology. 2002. Vol. 3. P. 175-182.

Caims J. Aging and cancer as genetic phenomena // Natl. Cancer Inst. Monogr. 1982. Vol. 60. P. 237-239.

Calvert R. J., BuzardG. S., Anisimov V. N., Rice J. M. K-ras codon 12 point mutations in bromodeoxyuridine- and N-nitrodosomethylurea-induced rat renal mesen-chymal tumors // Cancer Lett. 1996. Vol. 106. P. 1-7.

 

Cameron I. L. Minimum number of cell doubling in an epithelial cells population during the lifespan of the mouse // J. Gerontol. 1972. Vol.27. P. 157- 161.

 

Campisi J. From cells to organisms: can we learn bout aging from cells in culture // Exp. Cerontol. 2001. Vol. 36. P. 607-618.

Campisi J. Cancer and ageing: rival demons? // Nat. Rev. Cancer. 2003. Vol. 3. p. 339-349.

Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes // Exp. Gerontol. 2003. Vol. 38. P. 5--11.

Campisi J., Kim S., Lint C. S., Rubio M. Cellular senescence, cancer and aging: the telomere connection// BxpGeromol. 2001. Vol. 36. P. 1619-1637.

Cardozo Petaez F., Song S., Parthasarathy A, et al. Attenuation of age-dependent oxidative damage to DNA and protein in braitistcm of T^ Cu/Zn SOD mice//Neurobiol. Aging. 1998. Vol. 19. P. 311-316.

 

Carey J. R., Judge D. S. Life Spans of Mammals, Birds, Amphibians, Reptiles, and Fish Series Title: Odense Monographs on Population Aging Series No. 8. Odense: Odense University Press Year, 2000. 214 p.

 

Carey J. R., Liedo P., Harshman L. et al. Life history response of Mediterranian fruit flies to dietary restriction//Aging Cell. 2002. Vol. 1. P. 140-148.

 

Carrilo М. С. Favre С, Carnovale СЕ. el al. Involvement of ji class gluta-thione S-iransferase subimil M2 (rGST M2) levels in the initiation and promotion of hepatocarcinogenesis in old rats // Exp. Gerontol. 2001. Vol. 36. P. 255-265.

 

Cartee G. ?>., Kietz E. W., Briggs-Tung С Adaptation of muscle glucose transport with caloric restriction in adult, middle-aged and old rats // Am. J. Physiol. 1994. Vol. 266. P. RI443-R147.

 

Casciano D. A., Ckou M., Lyn-Cook L E., Aiidoo A. Calorie restriction modu-ates chemicaHy induced in vivo somatic mutation frequencz // Environ. Mol. Mutagen. 1996, Vol. 27. P. 162-164.

 

Catania J., Fairweather D. S. DNA methylation. and cellular aging // Mutat. Res. 1991. Vol. 256. P. 283-293.

Cebalos Picoi /. Transgenic mice overexpressing copper-zinc superoxide dismu-tase: a model for the study of radical mechanisms and aging // C. R. Seances Soc. Bio. Fil. 1993. Vol. 187. P. 308-323.

 

Chang К. Т., Min K.-T. Regulation of lifespan by histone deacetylase // Ageing Res. Rev. 2002. Vol. 1. P. 313-326.

Ci\en J. В., Sun J., Jazwinstd S. M. Prolongation of the yeast life span by the v-Ha-RAS oncogene // MoL Microbiol. 1990. Vol. 4. P. 2081-2086.

Chin C. P., Dragowska W., Kim N. W. et al. Differential expression of telom-erase activity in hematopoietic progenitors from adult human bone marrow // Stem Cells. 1996. Vol. 14. P. 239-248.

 

ChowM., Rubin H. Gonal selection versus genetic instability as the driving force in neoplastic transformation // Cancer Res. 2000. Vol. 60. P. 6510-6518.

 

Clancy D. J., Gems D., Harslmum L G. el al. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein // Science. 2001. Vol. 29Z P. 104-106.

 

Clapp N. K., Sattetfieid L C. Bowles N. D, Effects of the antioxidant butylated hydroxytoluene (BHT) on mortality in BALB/c mice // J. Gerontol. 1979. Vol. 34. P. 497-501.

 

devenger C. V, A old epithelial cell never dies, it just agonesces away // Trends Endocrinol. Metab. 2001. Vol. 12. P. 183-184.

Colangelo L A., GapsturS.M., GannP. H. et al. Colorectal cancer mortality and factors related to the insulin resistance syndrome // Cancer Epidemiol. Bio-markers Prev. 2002 Vol. 4. P. 385-391.

 

Coleman G. L., Bernard C. C, Bernard O, Bcl-2 transgenic mice with increased number of neurons have a greater leamig capacity // Brain Res. 2000. Vol. 832. P. 188-194.

 

Coles L. S. Table of world-wide living supercentenarians // J. Anti-Aging Med. 2002. Vol. 5. P. 397-399.

Coller H. A., Khrapko K., Bodyak N. D. et al. High frequency of homoplasmic mitoctondrial DNA mutations in human tumors can be explained wittout selection // Nature Genet. 2001. Vol. 28. P. 147-150.

 

Cotman M. S., Afshari С A., Barrett J. С Regulation of p53 stability and activity in response to genotoxic stress // Mutat, Res. 2000. Vol. 462. P. 179-188.

 

Comfort A., Youhotsky-Gore L, Pathmanathan K. Effect of ethoxyquin on the longevity of C3H mice// Nature (London). 1971. Vol. 229. P. 254-255.

Cotui A., Maestroni C J. Melatonin rhythms in mice: role in autoimmune and lymphoproliferative diseases. Ann. New York Acad. Sci. 1998. Vol. 840. P. 395-410.

 

Coppola R, Mari D., Lattuada A, Fnmcesci C. Von Willebrand factor in Italian centenarians // Haematologica. 2003. Vol. 88. P. 39-43.

Corpus ?., Harmon S. M., Pineyro M. A. et al. Continuous subcutaneous infusions of growth hormone (GH) releasing hormone 1-44 for 14 days increase GH and insultn-like growth factor-! levels in old men//J. Clin, Endocrinol- Metat>. 1993. Vol. 76. P. 134-138.

 

Coschigano К. Т., Clemmons D., Bellush L. L, Kopchick J. J. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice // Endocrinology. 2000. Vol. 141. P. 2608-2613.

 

CotziasG. C, Miller S, Т., Nicholson A. R. et al. Prolongation of the life-span in mice adated to large amounts of L-Dopa // Proc. Natl. Acad. Sci. USA. 1974. Vol. 71. P. 2466-2469.

 

Counter С. М" Gupta J., Harley С. В. et al. Telomerase activity in normal leukocytes and in hematalogic malignancies // Blood. 1995. Vol. 85. P. 2315-2320.

 

Craddock V. M. Shortening of tlie life span caused by administration of 5-bro-modeoxyuridine to neonatal rats // ChenvBiol. Interact. 1981. Vol. 35. P. 139-144.

 

Cristofalo V. J., Allen R. G., Ptgnolo R. J. et al. Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation // Proc. Natl. Acad. Sci. USA. 1998. Vol. 95. P. 10614-10619.

 

Crow J. F. The high spontaneous mutation rate: is it a health risk? // Proc. Natl. Acad. Sci. USA. 1997. Vol. 94. P. 8380-8386.

Crowtey C, Curtis H. J. Tl" development of somatic mutations in mice with age // Proc. Natl. Acad. Sci. USA. 1963. Vol. 49. P. 625-628.

Cullen B. R, Bick M. D., Thermal denaturation of DNA from bromodeoxyurdne substituted cells // Nucleic Acids Res. 1976. Vol. 3. P. 49-62.

Ciunmings D, E., Merriam С R. Growth hormone therapy in adults // Annu. Rev. Mcd. 2003. Vol. 54. P. 513-533.

Cutler R. Human longevity and aging: possible role of reactive oxygen species // Ann. N. Y. Acad. Sci.1991. Vol. 621. P. 1-28.

Cutler R. Oxidative stress: its potential relevance to human disease and longevity determinants // Age. 1995. Vol. 18. P. 91-96.

Danizer F., Schreiber V., Nidergag С et al. Involvement of poly(ADP-ribose) polymerase in base excision repair//Biochimie. 1999. Vol. 81. P. 69^-75.

Dasgupta S. A computer simulation for biological aging // J. de physique. 1994. Vol.4. P. 1563-1570.

Davidson R. L, Broeker P., Ashman С R. DNA base sequence changes and sequence specificity of bromodeoxyuridine-induced mutations in mammalian cells // Proc. Natl. Acad. Sci. USA. 1988. Vol. 85. P. 4406-i4(0.

 

De Benedicts G., Rose C, Carrieri С et al. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans // FASEB J. 1999. Vol. 13. P. 1532-1536.

 

De Benedictis G., Tan Q., Jeune B. et al. Recent advances in human gene-longevity association studies // Mech. Ageing Dev. 2001. Vol. 122. P. 909-920.

De Boer J., van der Horsi G, Т., Hoeijmakers J. H. Mutant mice as a model of human diseases of aging. Defective transcription and premature aging // Tijdscr Gerontol. Ceriatr. 1999. Vol. 30. P. 168-170.

 

De Grey A, D, The reductive hotspot hypothesis: un update // Arch. Biochem. Biophys. 2000. Vol. 373. P. 295-301.

De Grey A. D.N.J. The reductive hotspot hypothesis of mammalian aging. Membrane metabolism magnifies mutant mitochondrial mischief// Eur. J. Biochem. 2002. Vol. 269. P. 2003-2009.

 

De Haan G., Van Zant G. Dynamic changes in mouse nematopoietic stem cell numbers during aging//Blood. 1999. Vol. 15. P. 3294-3301.

De Haan C, Gelman R., Watson A. A putative gene causes variability in lifespan among genotypicall у identical mice //Nature Genet. 1998.Vol. 19.P. J14--116.

 

Dean D. J., BrozinickJ. Т., Cushman S. W., Cartee G. D. Calorie restriction increases cell-surface GLUT4 in insulin-stimulated skeletal muscle // Am J. Physiol. 1998. Vol. 275. P. E957-E964.

 

Dean W, Biological Aging Measurement - Clinical Applications. Los Angeles, 1986.397 р.

Dean W. Biological aging measurement // J. Gerontogeriatrics. 1998. Vol. 1. P. <>4-85.

Dear K. B. G., SatazarM., Watson A. L. M. et al. Traits that influence longevity in mice: a second look // Genetics. 1992. Vol. 132. P. 229-239.

DeCoursey P. J., Krulas J. R. Behavior of SCN-lesioned chipmunks in natural habitat: a pilot study // J. Biol. Rhythms. 1998. Vol. 13. P. 229-244.

DeCoursey P, J., Walker J, K., Smith S. A. A circadian pacemaker in free-living chipmunks: essential for survival? // J. Сотр. Physiol. [A]. 2000. Vol. 186. P. 169-180.

 

Deerberg F., Bartsch C, Pohlmeyer G., Barisch H. Effect of melatonin and physiological epiphysectomy on the developmet of spontaneous endometrial carcinoma in BDII/HAN rats. Cancer Biother Radiopharmacol. 1997. Vol. 12. P. 420.

 

Dempsey J. L, Pfeiffer M., Morley A. A. Effect of dietary restriction on in vivo somatic mutation in mice // Mutat. Res. 1993. Vol. 291. P. 141-145.

De Pinho R. A. The age of cancer // Nature. 2000. Vol. 408. P. 248-254.

De Errico M., Calcagmie A, S., Corona R. et al. p53 mutations and chromosome instability in basal cell carcinomas developed at an early or late age // Cancer Res. 1997. Vol. 57. P. 747-752.

 

Deshaies R. J. SCF and culliti/ring H2-based ubiquilin Hgases // Annu. Rev. Cell Pev. Biol. 1999. Vol. 15. P. 435-467.

DHoog R., Hartmann D., Manil et al Neuromotor alterations and cerebellar deficits in aged arylsulfatase -deficient transgenicmice // Neurosci. Lett. 1999. Vol.273. P. 93-96.

 

DiPaolo S. A. Polydactylism in the offspring of mice injected with 5-bromo-deoxyuridine // Science. 1984. Vol. 145. P. 501-503.

Dickson M. A., Hah W. C, /no Y, et al. Human keratoincytes that express hTERT and also bypass a pl6(iNK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics // Mol. Cell. Biol. 2000. Vo). 20. P. 1436-1447.

 

Difilippantonio M. J., Zhu J., Cheng H. T. et al. DNA repair protein KuSO suppresses chromosomal aberrations and malignant transformation // Nature. 2000. Vol. 404. P. 510-514.

 

Oilman V. M, Age-associated elevation of hypothalamic threshold to feedback control and its role in development, aging and disease // Lancet 1971. Vol. 1. P. 1211-1219.

 

Oilman V. M. Development, Aging and Disease. A New Rationale for an Intervention Strategy. Chun Harwood Academic Publ., 1994, 387 p.

Oilman V. M., Anisimov V.N. Hypothalamic mechanism of ageing and of specific щс paihdngy. I. Sensitivity threslwld of hypoihalamo-pitoitary complex to homeostatic stimuli in thercporductive system// Exp. Geront. 1979. Vol. 14. P. 161-174.

 

Oilman V. M., Anisimov V. N. Effect of treatment with phenofrornin, diphenyl-hydantoin or L-DOPA on life span and tumor incidence in C3H/Sn mice // Gerontology. 1980. Vol. 26. P. 241-245.

 

Oilman V. M., Anisimov V. N., Ostroumova M. N. et al. Increase in life span of rats following polipeptide pineal extract treatment // Exp. Pathol. 1979. Vol. 17. P. 539-545.

 

Oilman V. M., Bobrov J. F., Ostroumova M. N. et al Hypothalamic mechanisms of ageing and of specific age pathology-IH. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in energy systems // Exp. Gerontol. 1979. Vol. 14. P. 217-224.

 

Oilman V. M., Ostroumova M. N, TsytiinaE. V. Hypothalarnjc mechanisms of ageing and of specific age pathology-11. The sensitivity threshold of hypoihalamo-pituitary complex to homeostatic stimuli in adaptive homestasis // Exp. Gerontol. 1979. Vol. 14. P. 175-181.

 

Dimri G. P., Lee X., Basile C. et al. A novel biomarker that identifies senescent human cells in culture and in aging skin in vivo // Proc. Nail. Acad. Sci. USA. 1995. Vol. 92. P. 9263-9367.

 

Dix D. On the role of gene relative to the environment incarcinogenesis/ZMech. Ageing Dev. 2003. Vol. 1. P. 323-332.

Dix D., Cohen P. On the role of aging incarcinogenesis// Anticancer Res. 1999. Vol. 19. P. 723-726,

Dix D., Cohen P., FlanneryJ. On the role of aging in cancer incidence // i. Theor.Biol. 1980. Vol.83. P. 163-173.

Ooblhammer C, Vaupel J. W. Lifespan depends on month of birth // Proc. Natl, Acad. Sci. USA. 2001. Vol. 98. P. 2934-2939.

Dockerty J. D., Draper G-, Vincent T. et al. Case-control study of parental age, party and socioeconomic level in relation to childhood cancers // Int. J. Epidemiol. 2001. Vol. 30. P. 1438-1439.

 

Dolle M. E. Т., Snyder W. K., Gosstn J. A. et al. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine // Proc. Natl. Acad. Sci. USA. 2000. Vol. 97. P. 8403-8408.

 

Dolle M. E., Snyder W. K., Duttson D. В., Vijg J. Mutational fingerprints of aging // Nucleic Acids Res. 2002. Vol. 30. P. 545-549.

DonehowerL. A. Does p53 affect organismal aging? // J. Cell. Physiol. 2002. Vol. 192. P. 23-33.

Donehower L, A., Harvey M., Vogel H. et at. Effects of genetic background on tu-morigenesisirip53-deficienimice//Mol. Carcinogenesis. 1995. Vol. 14. P. 16-2Z

 

Dozmorov I., Bartke A., Miller R. A. Array-based expression analysis of mouse liver genes: effect of age and of the longevity mutant Propldf // J. Gerontol. A Biol. Sci. Med. Sci. 2001. Vol. 56. P. B72-B80.

 

Du M, Q., Carmichael P. L., Phillips D. H. Induction of activated mutations in the human c-Ha-ras proto-oncogene by oxygen free radicals // Mol. Carcinogenesis. 1994. Vol. 11. P. 170-175.

 

Duffy P., Feuers R. J., Leaney J, et al. Effect of chronic caloric restriction on physiological variables related to energy metabolism n the male Fischer 344 rat // Mech. Agetn Dev. 1989. Vol. 48. P. 117-133.

 

Dufour E., Boulay J., Rincheval V., Sa'wsard-Chanet A A causal link between respiration and senescence in Podospora anserine II Proc. Natl. Acad. Sci. USA. 2000. Vol. 97. P. 4138-4143.

 

Duncan M. С., Chada К, K. incidence of tubulostromal adenoma of the ovary in aged germ eel-deficient mice // J. Сотр. Pathol. 1993. Vol. 109. P. 13-19.

 

Ebbesen P. Papilloma development on young and senescent mouse skin treated with )2-0-tetradecanoylphorbol 13-aoetate // Age-Related Factors in Carcinogenesis / Eds A. J. Likhachev, V. N. Anisimov, R. Montesano (IARC Sci. Publ. N 58). Lyon: IARC, 1985. P. 167-170.

 

Ebbesen P. Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors // J. Natl. Cancer, lnst. 1971. Vol. 47. P. 1241-1245.

 

Ebbiary N. A. A., Lenton E. A, Cooke I. D. Hypothalamic-pituitary ageing: progressive increase in FSH and LH concentrations throughout the reproductive life in regularly menstruating women//Clin. Endocrinol. 1994. Vol.41. P. 199-206.

 

Egan C. A., Savre-Train /., Shay J. W. et al. Analysis of telomere lenghts in human comeal endothelial cells from donoi-s of different ages // Invest. Ophthalmol. Vis. Sci. 1998. Vol. 39. P. 648-653.

 

EUatn R., Peter Y., Elson A. et al. Elective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice //Proc. NaL Acad. Sci. USA. 1998. Vol. 95. P. 12653-12636.

 

Elmore L W., Turner K. C, Collahon L S. et al. Telomerase protects cancer-prone human cells from chromosomal instability and spontaneous immortalization // Cancer Biol. Ther. 200Z Vol. I. P. 391-397.

 

Emamtel N. M, Kinetics and free-radical mechanisms of ageing and carcinogenesis // Age-Related Factors in Carcinogenesis / Eds A. J. Likhachev, V. N. Anisimov, R. Montesano. (IARC Sci. Publ. N 58). Lyon: 1ARC, 1985. P. 127-149.

 

Etnanuel L M., Obitkhova L K. Types of experimental delay in aging patterns // Exp. Gerontol. 1978. Vol. 13. P. 25-29.

Ershler W, B. Explanations for reduced tumor proliferative capacity with age // Exp. Gerontol. 1992. Vol. 27. P. 551-558.

EvanG., UttlewoodT. A matter of life and cell death//Science. 1998. Vol.281. P. 1317-1322.

Everitt A. V., Seedsman N. J., Jones F, The effects of hypophysectomy and continuous food restriction, begun at ages 70 and 400 days, on collagen aging, proteinuria, incidence of pathology and longevity in the male rat // Mech. Ageing Dev. 1980-Vol. 12. P. 161-172.

 

Ezzafi M., Иоот S. V., Rodgem A. et id. Estimates of global and regional poten-tional health gains from reducing multiple major risk factors // Lancet. 2003. Vol. 326. P. 271-290.

 

Fabris N. Neuroenocrine-immune interactions: a theoretical approach of aging // Arch. Gerontol. Geriatr. 1991. Vol. 12. P. 212-230.

Fabris N, Mocchegiani E., MuzzioU M., Provincialli M. Zinc, immunity and aging. // Goldstein A.L., ed. Biomedical Advances in Aging. N. Y.; London: Plenum Press, 1990. P. 271-281.

 

Facchini F. S., Him N. W., Reaven С M., Stoohs R. A. Hyperinsulinemia: the missing link among oxidative stress and age-related diseases? // Free Radical Biol. Med. 2000. Vol. 29. P. 1302-1306.

 

Fartie P. G., Dringen R, Rees S. M, et al. Bcl-2 transgene expression can protect neurons against developmental and induced cell death // Proc. Natl. Acad. Sci. USA. 1995. Vol. 92. P. 4397-^(401.

 

Ferbeyre G., Lowe S. W. The price of tumour suppression? // Nature. 2002. Vol.415. P. 26-27.

Finch С. Е. Longevity, Senescence, and the Genome. Chicago: Univ. Chicago Press, 1990.922 p.

Finch C. E Neurons, glia, and plasticity in normal brain agin| // Успехи герон-тол. 2002. Т. 10. С. 35-39.

Finch С. Е, Kirkwood Т. В. L, Chance, Deyeleoprnent, and Aging. N- V,: Oxford University Press, 2000.

Finch С, Е., LandfieidP. W. Neuroendocrine and autonomic functions in aging mammals // Handbook of the Biology of Aging. 2lld ed. / Eds С. Е. Finch, E. L. Schneider. N. Y.: Van Nostrabd Reinhold Co, 1985. P. 645-691.

 

Finch C. E., Ruvlam G. The genetics of aging // Ann, Rev. Gejiomics Hum, Genet. 2001. Vol. 2. P. 435-462.

Finch С ?., TaitztR. E. Genetics of aging //Science. 1997. Vol. 278. P. 407-411.

Finch G. L, March T. H., Hahn F. F. el al. Carcinogenic responses of iransgenic heterozygous p53 knockout mice to inhaled 2;t9PuO2 or metallic beryllium // Toxicol. Pathol. 1998. Vol. 26. P. 484-491.

 

Finkel Т., Holbrook N. J. Oxidants, oxidative stress and the biology of ageing // Nature. 2000. Vol. 408. P. 239-247.

Flurkey K., Papaconstantinou J., Miller R. A., Harrison D. E Life-span extension and delayed immune and collagen aging in mutant mice with defects in gowth hormone production //Proc. Natl. Acad. Sci. USA. 2001. Vol. 98. P. 6736-6741.

 

Forbes W.F. The effect of prednisolone phosphate on the life-span of DBA/2J mice // Exp. Gerontol. 1975, Vol. 10. P. 27-29.

Foster M., Solial B. H., SohalR. S. Reversible effects of long-term caloric restriction on protein oxidative damage // J. Gerontol. Biol. Sci. 2000. Vol. 55. P. B522-B529.

 

Fraga C. G., Shigenaga M. K., Park J. W, et al, Oxidative damage to DNA during aging 8-hydroxy-2'deoxyganosine in rat organ DNA and urine // Proc. Natl. Acad. Sci. USA. 1990. Vol. 87. P. 4533-^1537.

 

Franceschi С. Monti D., Sansoni P. et al. The immunology of exceptional individuals: the lesson of centenarians//Immunol. Today. 1995. Vol. 16.P. 12-16.

 

Franceschi C, Motta L, Valensin S. et al. Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians // Aging Clin. Exp. Res. 2000a. Vol. 12. P. 77-84.

 

Franceschi C, Bonafe /W., Valensin S. et al. Inflammo-aging: An evolutionary perspective on immunesenescnece // Ann. N. Y. Acad. Sci. 2000. Vol. 908. P. 244-254.

 

Freeman J. T. Aging: Its History and Literature. - N. Y.; London: Human Sciences Press, 1979. 161 p.

Freisteben H. J., Lehr F., Fuchs J. Lifespan of immunosuppressed NMRI-mice is increased by deprenyl//J. Neural Transtn. Suppl. 1994. Vol.41. P. 231-236.

 

Freisleben H. J., NeebA., LehrF., Ackermann H, Influence of selegiline and li-poic acid on the life expectancy of immunosuppressed mice // Arzneimittel-forschung. 1997. Vol. 47. P. 776-780.

 

Frofkis V. V. Hypothalamic mechanisms of aging and anti-aging // Neurophysio-logy. 1999. Vol. 31. P. 3-7.

Fu L. Pelicano H., Liu J. et al. The circadian gene Period2 plays an import nat role in tumor suppression and DNA damage response in vivo//Cell. 2002. Vol. 111. P. 41-50.

 

Gallagher D., Thompson L, W., Levy S. M. Clinical psychological assessment of older adults // Aging in the 1980"в: Psychological Issues. Washington, DC: Amer. Psycho!. Press, 1980. P. 19-40.

 

Gallagher I. M., JennerP., Glover V., Clow A. Cu, Zn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-azindol and 3H-spiperone binding over 19 months // Neurosci. Lett. 2000. Vol. 289. P. 221-223.

 

Galtimore P. H., became P. S., Roberts S. et al. Adenovirus type 12 early region IB 54K protein significantly extends the life span of normal mammalian cells in culture//J. Virol. 1997. Vol. 71. P. 6629-6640.

 

GarastoS., Rose G., Derango F. et aL The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects // Ann. Human Gen. 2003. Vol. 67. P. 54-62.

 

Gavrilova N. S., GavrilovLA. et al. Evolution, mutations, and human longevity: European royal and noble families // Human Biol. 1998. Vol. 70. P. 799-804.

 

GazievA. /., Solngub R. G., Fnmenko L A. et al. Effect of vitamin-antioxidant mi-cronutritients on the frequency of spontaneous and in vitro Y-ray-induced micronuclei in lymphocytes of donors; the age factors // Carcinogenesis. (9%, vol. 7- P. 493-499.

 

GemsG., PletcherS., Partridge L Interpreting interactions betwcn treatments tliat slow aging // Aging Cell. 2002. Vol. 1. P. 1-9.

Gerdes L U., Jeune В., Ranberg K, A, et al. Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a "frailty gene", not a "longevity gene" // Genet. Epidemiol. 2000. Vol. 19. P. 202-210.

 

German J. Bloom's syndrome//Dermatol. Clin. 1995. Vol. 13. P. 7-18.

Gershon D. The mitochondrial theory of aging: is the culprit a faulty disposal system rattier than indigenous mitochondrial alterations? // Exp. Gerontol. 1999. Vol.34. P. 613-619.

 

Geschickter С, F., Byrnes E.W, Factor influencing the development and time of appearance of mammary cancer in the rat in response to estrogen // Arch. Patlx>l. 1942. Vol. 33. P. 334-342.

 

Geula C, Wu С. K., SaroffD, et al. Aging renders the brain vulnerable to amyloid beta-rotein neurotoxicity // Nature Med. 1998. Vol. 4. P. 827-831.

Giese H., Snyder W. K., van Ooslman С et al. Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice // Mutat. Res. 2002. Vol. 514. P. 153-163.

 

Gladyshev G.P. Thermodynamic Theory of the Evolution of Living Being. New York: Nova Sci. Publ. Inc., 1997. 100 p.

Gladyshev G. P. Thermodynaniics theory of biological evolution and aging. Su-pramolecular thermodynamics is a key to understanding phenomena of life. What is life from a physical chemist's viewpoint // Успехи геронтол. 2002. Т. 9. С. 49-53.

 

Glassner В. J., Weeda G, Allan J. M. et al. DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylat-ing agents // Mutagenesis. 1999. Vol. 14. P. 339-347.

 

Globerson A. R., Abel E 1., Ben-Menahem D. Developmental aspects of T-lym-phocytes in aging // Goldstein A. L., ed. Biornedical Advances in Aging. New York; London: Plenum Press, 1990. P. 363-373.

 

GoffeauA., Barrel! B. G, BusseyH, et al. Life with 6000 genes // Science. 1996. Vol. 274. P. 563-567.

Goldstein S. Replicative senescence: The human fibroblast comes of age // Science. 1990. Vol. 249. P. 1129-1133.

Gompertz B. On the Nature of the Function Expressive of the Law of Human Mortality. Phil. Trans. Royal Soc. (London). 1825.

Gonzalez-Suarez, E., Flores J. M., BlascoM.A. Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development // Mol. Cell Biol. 2002. Vol. 22. P. 7291-7301.

 

Gonzalez-Suarez E., Samper E., Flores J. M., Blasco M. A. Teomerase-deficient mice with short telomeres are resistant to skin tomorigenesis // Nature Genet. 2000. Vol.26. P. 114-117.

 

GrafM. V., Kastin A. J. Delta-sleep-induqng peptide (DSIP): an update // Pep-tides. 1986. Vol. 7. P. 1165-1187.

Grasl-Kraupp В., Bursh IK, Ruttkay-Nedecky B, et al. Food restriction elimiates pieneopla&tic cells through apoptosos and antagonizes carcinogenesis in rat liver // Proc. Nail. Acad. Sci. USA. 1994. Vol. 91. P. 9995-9999.

 

Green D. R., Evan G.I. A matter of life and death // Cancer Cell. 2002. Vol. I. P. 19-30.

Greenberg R, A., Chin L., Femino A. et al. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse // Cell. 1999. Vol.97. P. 515-525.

 

Greider С W., Blackburn ? H. Identification of a specific telomer terminal transferase enzyme with two kinds of primer secificily // Cell. 1985. Vol.51, p. 405-413.

 

Gu Y., Seidi K. J., Rathbun G. A. et al. Growth retardation and leakey SCIP plienotype of Ku70-deficient mice // Immunity. 1997. Vol. 7. P. 653-665.

Gitarente L., Kenyon С. Cenetliic pathways that regulate ageing in model organisms // Nature. 2000. Vol. 408. P. 255-262.

Cubin D., Ciibin G. Sonic general effects of aging upon circadian parameters of cardiovascular variables assessed longitudinally by ambulatory monitoring // Chro-nobiol. Internal. 2001. Vol. 18. P. U06-1107.

 

Culezian D., Jacobson-Kram D., McCullough C. B. et al Use of transgenic animals for carcinogenicity testing: considerations and imlications for risk assessment // Toxicol. Pathol. 2000. Vol. 28. P. 482^99.

 

GuptaK., Krishnaswamy G. KarnadA., PeirisA. N. Insulin: a novel factor in carcinogenesis // Am. J. Med. Sci. 2002. Vol. 323. P. 140-145.

Madden J. IV. Thymic endocrinology // Ann. N. Y. Acad. Sci. 1998. Vol. 840. P. 352-358.

Halm W. C, Counter C. M., Lundberg A. S. et al. Creation of human tumour cells with defined genetic elements//Nature. 1999. Vol.400. P. 464-468.

Hamihon M. L., Van Rentmen H., Drake J. A. et al. Does oxidalive damage to DNA increase with age?// Proc. Natl. Acad. Sci. USA. 2001. Vol. 98. P. 10469-10474.

 

HampelB., Unterluggauer H,. Jansen-Durr P., ErdelM. Age-related poly-ploidization and cell death in senescent human epitlielial cells // First Conference on Functional Genomics of Aging. April 24-27, 2002. Seville, Spain, 2002. P. 41.

 

Hanahan D., Weinberg R. A. The hallmarks of cancer // Cell. 2000. Vol. 100. P. 57-70.

Hansen В. С, Bodkin N. L Primary prevention of diabetes mellitus by prevention of obesity in monkeys //Diabetes. 1992. Vol.42. P. 1809-1814.

HaradaY.N., Shiomibl., Koike M. et ai. Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderrna pigrnentosum group G gene// Mol. Cell. Biol. 1999. Vol. 19. P. 2366-2372.

 

ИаНеуС.Б, Telornevase is not an oncogene // Oncogene. 2002, Vol 21. p. 494-50Z

HarmanD. Extending functional life span // Exp. Gerontol. 1998. Vol.33. P. 95-112.

Harmon D. Free-radical theory of aging: increasing the functional life span // Ann. N. Y. Acad. Sci. 1994. Vol. 717. P. 257-266.

Haroutunian V., Zhou Y., Elder G. et al. Age-dependent spatial memory deficits in transgenic mice expressing the human mid-sized neurofilament gene // Brain Res. Mol. Brain Res. 1996. Vol. 42. P. 62-70.

 

Harrison D. E., Archer J. R. Natural selection for extended longevity from food restriction // Growth Dev. Aging. 1989. Vol. 53. P. 3.

Harrison D. E., Archer J. R., Astle С. М, Effects of food restriction on aging: separation of food intake and adiposity// Proc. Natl. Acad. Sci. USA. 1984. Vol. 82. P. 1835-1838.

 

Harrison D. E., Astle C. M., Delaittre J. A, Lost of proltferative capacity in im-inunohemopoietic stem cells caused by serial transplantation rather than ageing // J. Exp. Med. 1978. Vol. 147. P. 1526-1531.

 

Harvey Si., Vogel H., Lee E. У. et al. Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin //Cancer Res. 1995. Vol. 55. P. 1146-1151.

 

Hasty P., Camptsi J., Hoeijmakers J. et al. Aging and genome maintenance: lessons from the mouse?//Science. 2003. Vol. 299. P. 1355-1359.

Hatzinger M., Reul J. M., LandgrafR. et al. Combined dexamethasone/CRH test in rats: hypothalamo-pituitary-adrenocortical system alterations in aging // Neuro-endocrinology. 1996. Vol. 64. P. 349-356.

 

Hayashizaki Y. RIKEN mouse genome encyclopedia // First Conf. on Functional Genmics of Ageing, April 24-27, 2002. Seville, Spain, Delegate Manual, 2002, Abstr. 022.

 

Hayfiick L How and why we age // Exp. Cerontol. 1998. Vol. 33. P. 639-653.

Hayftick L New approaches to old age // Nature. 2000. Vol. 403. P. 365.

Hayflick L, Moorhead P. S, The serial cultivation of human diploid cell strains // Exp. Cell Res. 1961. Vol. 25. P. 585-621.

Hazmrd D. G., Soban J. Studies of aging using genetically defined rodents. A bibliography//Exp. Aging Res. 1988. Vol. 14. P. 59-81.

Heidrick M.L. Hendricks L C, Cook D. E. Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3Fi mice// Mech. Ageing Dev. 1984. Vol.27. P. 341-358.

 

Hekimi S., Gitarente L. Genetics and the specificity of the aging process // Science. 2003. Vol. 299. P. 1351-1354.

Hemminki K., Kyyronen P. Parental age and risk of sporadic and familial cancer in offspring: implications for germcell mutagenesis // Epidemiology. 1999. Vol. 10. P. 747-751.

 

Hemiings #., Boutwell R. K. Studies on the mechanism of skin tumpr promotion // Cancer Res. 1970. Vol. 30. P. 312-320.

Herndon L A., Schmeissner P. J., Dudaronek J. M. et al. Stochastic and genetic factors influence tissue-specific decline in ageing С elegans II Nature. 2002. Vol. 419. P. 808-814.

 

Herrera E., Samper E., Martin Caballero J. et al. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres // EMBO J. 1999. Vol. 18. P. 2950-2960.

 

Heston W, E. Testing the antifenility drug Enovid for carcinogenesis in five strains of mice // J. Toxicol. Environ. Health. 1976. Suppl. 1. P. 257-266.

 

Hirokawa K., Utsuyama M. Animal models and possible human application of immunological restoration in the elderly // Mech. Ageing Dev. 2002. Vol. 123. P. 1055-1063.

 

Hirose N., Kawamura M., Ami У. et al. Polymorphismm of apo E and Lp(a) phenotype // Eds Centenarians in Japan / H. Tauichi, T. Sato, T Watanabe. Tokyo: Nakayamashoten, 1997. P. 165-171.

 

HochschildR. Effect of dimethylaminoethyl p-chlorophenoxyaceiate on the life span of male Swiss Webster Albino mice//Exp. Gerontol. 1973. Vol. 8. P. 177-183.

 

Hockenbery D., Nunes G., MHliman C. et a}. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death // Nature. 1990. Vol. 348. P. 334-336.

 

Hogan В., Beddington R., Constantini F., Lacy E. Manipulating the Mouse Embryo. Plainview: Cold Spring Harbor Laboratory Press, 1994.

Holliday R, Food, reproduction, and longevity: Is the extended lifespan of calone-restricted animals an evolutionary adaptation?// BioEssays. 1989. Vol. 10. P. 125-127.

 

HolzenbergerM., DupondJ., Ducos B, et al. 1GF-1 receptor regulates lifespart and resistance to oxidative stress in mice//Nature. 2003. Vol. 421. P. 182-187.

 

Hornsby P. J. Celleular senescence and tissue aging in vivo // J. Gerontol. Biol. Sci. 2002. Vol. 57A. P. B251-B256.

Hosokawa M. A higher oxidative status accelerates senescence and aggravates age-related disorders in SAMP strains of mice // Mech. Ageing Dev. 2002. Vol. 123. P. 1553-1561.

 

Hosokawa M., Fujisawa H, Ax S. et al Age-associated DNA damage is accelerated in the senescence-accelerated mice // Mech. Ageing Dev. 2000. Vol. 118. P. 61-70.

 

Howiiz K. T. Small molecule activators of sirtuins extend Saccharamyces cere-visiae lifespan// Nature. Published online: doi: 10.1038/nature01960 (2003).

 

Hsiao K. K., Bochelt D. R., Olson K. et al. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins//Neuron. 1995. Vol. 15. P. 1203-1218.

 

Hsieh C. C, DeFord J. H., Fturkey K. et ai Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. etegans longevity paradigm //Mech. Ageing Dev. 2002. Vol. 123. P. 1229-1244.

 

Hsieh C. C, DeFord J. H., Flurkey K. et al. Effects of the Pit) mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse//Mech. Ageing. Dev. 2002a. Vol. 123. P. 1245-1255.

 

HurdM. W., Ralph M, R. The significance of circadian organization for longevity in the golden hamster //J. Biol. Rhythms. 1998. Vol. 13. P. 430-436.

Hursting S, u, Perkins S. N., Haines D. C. et al. Chemoprevention of spontaneous tumorigenesis in p53-knockout mice // Cancer Res. 1995. Vol. 55. P. 3949-3953.

 

Hussahi S. R., Hofseih L. J., Harris С. С Radical causes of cancer // Nature Rev. Cancer. 2003. Vol. 3. P. 276^-285.

IARC Monographs on the Evaluation of the Carcinoenic Risk of Chemcials to Humans. Vol. 21. Se* Hormones (II). Lyonr IARC, 1979. 583 p.

/llarioshkin S. JV-, ivanova-S/ttolenskaya I. A., Markova E. D. et al. Lack of -synuclein genemutation in families with autosomaldominant Parkinson's disease in Russia//J. Neurol. 2000. Vol. 247. P. 968-^969.

 

Ingram D. K., Jucker M. Developing mouse models of aging: a consideration of strain differences in age-related behavioral and neural parameters // Neurbiol. Aging. 1999. Vol. 20. P. 137-145.

 

Ingram D. /C, Nakamura K, Smucny D. et at. Strategy for identifying biomarkers of aging in long-lived species // Exp. Cerontol. 2001. Vol. 36. P. 1025-1034.

 

ishikawaF. Aging clocj;: the watchmaker's masterpiece // Cell Mo), Life Sci. 2000. Vol. 57. P. 698-704.

Ivancsits $., Diem ?., Jatm O., Rudiger H. W. Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields // Mech. Ageing Dev. 2003. Vol. 124. P. 847-859.

 

IzmaytovD. M, Obukhova L. K. Geroprotector effectiveness of melatonin: investigation of lifespan of Drosophila melanogaster // Mech. Ageing Dev. 1999. Vol. 106. P. 233-240.

 

Jacks Т., Remington L., Williams В. О. et at. Tumor spectrum analysis in p53-mutantmice//Curr. Bio). 1997. Vol. 4. P. 1-7.

JacksonA. U., GaleckiA. Г., BurkeD. Т., MiUerR.A. Mouse loci associated with life span exhibit sex-secific and epistatic effects // J. Gerontol. Biol. Sci. 2001. Vol.57A. P. B9-B15.

 

James A. M., Murphy M. P. How mitochondrial damage affects cell funcion // J. Biomed. Svi. 2002. Vol. 9. P. 475-487.

Jazwinski S. M. Genetics of longevity // Exp. Gerontol. 1998. Vol. 33. P. 773-783.

Jazwinski S. M. Longevity, genes, and aging: a view provided by a genetic model system // Exp. Geront. 1999. Vol. 34. P. 1-6.

Jialal I., Devaraj S. Antioxidants and atherosclerosis. Don't throw out the baby with the bath water// Circulation. 2003. Vol. 107. P. 926-928.

Jiang X. R., Jimenez C, Chang E. et al, Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype // Na-tureGenet. 1999. Vol. 21. P. 111-114.

 

Johnson P. Ft., Stern J, S., Horwitz B. A, et al. Longevity in obese and lean male and female rats of the Zucker strain: prevention of hyperphagia // Am. J. Gin. Nutr. 1997. Vol. 66. P. 890-^903.

 

JourdanD., Piec L, Gatdier J.-M. etal. Effect of fenflluramine on caloric intake and micronutrient selection in Lou/c rats during aging // Neurobiol. Aging. 2003. Vol. 24. P. 67-76.

 

KatacheA, GattiA, Active ageing: a policy framework // Успехи геронтол. 2003. Т. 11. С. 7-18.

Kapaht P., Boulton M. ?., Kirkwood Т. В. L Positive correlation between mammalian life span and cellular resistance to stress // Free Radical Biol. Med. 1999. Vol. 26. P. 495-500.

 

KasparB. K., UadoJ., SherkatN. et al Retrograde viral delivery of IGF-1 prolongs survival in a mouse LA model // Science. 2003. Vol. 301. P. 839^-842.

Kaufman E. R. The role of deoxyribonucleotide metabolism in 5-bromo-2'-de-oxyuridine mutagenesis in mammalian cells//Mutat. Res. 1988. Vol. 200. P. 149-155.

 

Kawaguchi H., Manabe N., Miyaura C. et aL Independent impairment of os-teoblasts and osteoclasl differentiation in klotho mouse exhibiting low-turnover os-teopenia// J.CIin. Invest. 1999. Vol. 104. P. 229-237.

 

Rawanishi S., H'traki Y., Otkawa S. Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging // Mutat. Res. 2001. Vol. 488. P. 65-76.

 

Kayo Т., Allison D. В., Weindntch Ft., Prolla T.A. Influences of aging and caloric restriction on the transcriptiona] profile of skeletal muscle from rhesus monkeys // Proc. Natl. Acad. Sci. USA. 2001. Vol. 98. P. 5093-5098.

 

Kemnitz J. IV., Weindruch R., Roecker ? B. et al. Dietary restriction of adult male monkeys: design, methodology, and preliminary findings from the first year of study//J. Gerontol. 1993. Vol.48. P. B17-B26.

 

Kenyan C. A conserved regulatory system for aging // Cell. 2001. Vol. 105. P, 165-168,

Keyfitz N., Littman G. Mortality in a heterogeneous population // Population Studies. 1979. Vol. 33. P. 333-342.

Khatyavkin A. V. Influence of environment on the mortality pattern of potentially non-senescent organisms. General approach and comparison with real populations // Успехи геронтол. 2001. Т. 7. С. 46-49.

 

Khalyavkin А, V., Yashin A.I. How the analysis of genetic mutations can help us to solve basic problems in gerontology? I. Life extending genetic modifications in toynd worm C. eiegaiis II Успехи геронтол. 2003. Т. 11. С. 34-42.

 

Klmnsari D. И., Gustad Т. Effect of long-term, low-dose growth hormone therapy on immune function and life expectancy of mice // Mcch. Ageing Dev. 1991. Vol. 57. P. 87-100.

 

Khavinson V. Kh. Peptides and Ageing. Neuroendocrinol. Lett. 2002. Vol. 23. Suppl. 3. 144 p.

Khavinson V., Goncttarova N., Lapin B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys // Neuroendocrinol. Lett.

 

2001. Vol. 22. P. 251-254.

Khavinson V. K., izmaylovD. A/., Obukhova L. K., Malinin V, V. Effect of epitalon on the lifespan increase in Drosophila melanogaster // Mech. Ageing Dev. 2000. Vol. 120. P. 141-149.

 

Khavinson V. Kit., Morozov V. C, Anisimov V, N. Experimental studies of the pineal gland preparation epithalamin / Eds C. Bartsch, H. Bartsch, D. E. Blask et al. The Pineal Gland and Cancer. Neuroimmunoendocrine Mechanisms in Malignancy. Berlin: Springer, 2001. P. 294-306.

 

Khrapko K., Nekliaeva K, Kraytsberg K, Kunz W. Clona] expansion of mitochondria! genomes: implicatons for in vivo mutaton spectra // Mutat. Res. 2003. Vol.522. P. 13-19.

 

KimS., Kaminker P., Cainpisi J. Telomeres, aging and cancer: in search of a happy ending //Oncogene. 2002. Vol.21. P. 503-511.

Kimura K. D., Tissenbawn H, A., Uu Y., Ruvkun С daf-2, an insulin receptor-like gene thai regulated longevity and diapause in Caenoritabditis elegans II Science. 1997. Vol. 277. P. 942-946.

 

KtnzierK. W., Vogelstein B. Gatekeepers and caretakers // Nature. 1997. Vol. 386. P. 761-763.

Kipling D., FaragfterR. G. A. Ageing hard or hardly ageing? // Nature. 1999. Vol, 398. P. 191-192.

Kirk D. Demographic transition theory // Popul. Stud. 1996. Vol. 50. P. 361-387.

Kirk K, L. Dietary restriction and aging: comparative tests of evolutionary hypotheses//.!. Cerontol. A Biol. Sci. Med. Sci. 2001. Vol.56. P. В123-B129.

 

Kirkwood T.B.L Evolution of ageing // Mech. Ageing Dev. 2002. Vol. 123. p. 737-745.

Kirkwood T. B.L, The evolution of ageing and longevity // Phil. Trans. Roy. Soc. London. 1997. Vol. B352. P. 1765-1772.

Kirkwood T. B. L, Auslad & N. Why do we age // Nature. 2000. Vol. 408. P. 233-238.

Kirkwood T. B. L., Finch С E. The old worms turns more slowly // Nature, 2002. Vol. 419. P.794-795.

Kishi S., UchiyamaJ., BaughmanA.M. et al. The zebrafish as a vertebrate model of functional aging and very gradual senescence // Exp. Getontol. 2003. Vol. 38. P. 777-786.

 

Kitani К., Kanai S., Carrilto A/. C, Ivy G. H. (-)Eteprenyl increases the life span as well as activities of superoxide dismutase and catalase but not of glutathione per-oxidase in selective brain regions in Fisher rats // Ann. N. V. Acad. Sci. 1994. Vol.717.P.60-71.

 

Kitani K., Minami C, Isobe K. el at. Why (-) deprenyl prolongs survival of experimental animals: Increase of anti-oxidase enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effect // Mech. Ageing Dev. 2002. Vol. 123. P. 1087-1100.

 

KlyonoT., FosterS. A., KoopJ. I. et at. BothRb/pl6 (INK4a > inactivation and telomerase activity are required to immortalize human epithelial cells //Nature. 1998. Vol. 3%. P. 84-88.

 

Klungland A., Rosewett!., HollenbachS. Accumuation of premutagenic DNA lesions in mice defective in removal of oxidative base damage // Proc. Natl. Acad. Sci. USA. 1999. Vol. 96. P. 13300-13305.

 

Knapp J. /?., Kopchik J. J. The use of transgenic mice in nutrition research II J. Nutr. 1994. Vol. 124. P. 461-468.

Koim R. R-, Ceratni A., Monnier V. M. Collagen aging in vitro by nonenzyrnatic glycosylation and browning // Diabetes. 1984. Vol. 33. P. 57-59.

Kohn R. R. Effect of antioxjdants on life-span of C57BL mice // J. Gerontpl. 1971. Vol. 26. P. 378-380.

Koletsky S., Puterman D.I. Effect of low calorie diet on the hyperlipidemia, hypertension, and life span of genetically obese rats//Proc. Soc. Exp. Bjol. Med. 1976. Vol. 151. P. 368-371.

 

Kolto\er V. K. Reliability concept as a trend ip biophysics of aging // Theqr. Biol. 1997. Vol. 184. P. 157-163.

Kopchik J. J., Laron Z. Is the Laron mouse an accurate model of Laron Syndrome? // Mol. Genet. Metab. 1999. Vol. 68. P. 232-236.

KorpelaiiKii И, Human life histories and the demographic transition: A case study from Finland, 1870-1949//Am. J. Phys. Anthropol. 2003. Vol. 120. P. 384-390.

 

Kothari L. Influence of chronic melatonin on 9,10-dimethyl-lI2-benzanihrazene-induced mammary tumors in female Holtzman rats exposed to continuous light // Oncology. 1987. Vol. 44. P. 64-66.

 

KowaldA. Lifespan does not measure ageing // Biogerontology. 2001. Vol. 3. P. 187-190.

Kraupp-Grasl В., HuberW., Taper H., Scludte-Hermann R. Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously // Cancer Res. 1991. Vol. 51. P. 666-671.

 

Kraytsberg Y., Nekhaeva E, Bodyak N. В., Khrapko K. Mutation and inlracellu-lar clonal expamsion of mitochondrial genomes: two synergstic components of the aging process? // Mech. Ageing Dev. 2003. Vol. 124. P. 49-53.

 

Kroes R., Garbh-Berkvem J. M., de Vries Т., van Nessetrooy И. J, Histopa-thological profile of a Wistar rat stock including a survey of the literature // J. Ceron-tol. 1981. Vol. 36. P. 259-279.

 

Krtolica A., Campisi J. Cancer and aging: a model for the cancer promoting effects of the aging sttoma// Int. J. Biochern. Cell Bio|. 2002. Vol. 34- P. 1401-1414,

 

Krtolica A., Campisi J. Integrating epithelal cancer, aging stroma and cellular senscence // Успехи геронтол. 2003. Т. 11. С. 109-116.

Krtolica A, Parinelio S., Locckeit S. et at. Senescent fibroblasts promote epithelial cell growth and lumorigenesis: a link between cancer and aging // Proc. Natl. Acad. Sci. USA. 2001. Vol. 98. P. 12072-12077.

 

Kruszewski F, H., Conli C. J., DiGiovanm J. Characterization of skin tumor promotion and progression by chrysarobin in SENCAR mice It Cancer Res. 1987. Vol. 47. P. 3783-3790.

 

Kunisada Т., DannerD., Friedman V., Schneider E, L Increased susceptibility to SV40 transformation with development and in vitro aging // Exp. Cell Res. 1990. Vol. 189. P. 222-226.

 

Kuro-oM., MatsumuraY., AizawaH. et ai Mutation of the mouse kiotho gene leads to a syndrome resembling ageing // Nature. 1997. Vol. 390. P. 45-51.

LaBella F. S., Vivian S. Effect of p-aminoproponitrile or prednisolone on survival of male LAFj mice//Exp. Gerontol. 1975. Vol. 10. P. 185-188.

Lacetle C, Xu S., Wang К Identification of high caspase-3 tnRNA expression as a unique signature profile for extremely old individuals // Mecti. Ageing Dev. 2002. Vol. 123. P. 1133-1144.

 

Lakatta E. G. Age-related alteration in the caridovascular response to adrenergic mediatr stress //Fed. Proc. 1980. Vol. 39. P. 3173-3177.

Lambert В., Ringbord U., Skoog L. Age-related decrease of ultraviolet light-induced DNA repair synthesis in human peripheral leukocytes // Cancer Res. 1979. Vol. 39. P. 2792-2795.

 

Lanari C. Luthy I., Lamb С A. et at. Five novel hormone-responsive cell lines derived from murine mammary ductal carcinomas: in vivo and in vitro effects of estrogens and progestins // Cancer Res. 2001. Vol. 61. P. 293-302.

 

Lane M A, BaerD. J., TilmontE. M. et al. Energy balance in rhesus monkeys (Macaca mutatta) subjected to long-term dietary restriction // J. Gerontol. A Bjol. Sci. Med. Sci. 1995. Vol. 50. P. B295-B3O2.

 

Lau L L., Spain L M. Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice // Mech. Aging Dev, 2000. Vol. 111.P. 101-121.

 

LebelM., CardiffR, D., LederP. Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase // Cancer Res. 2001. Vol. 61. P. 1816-1819.

 

Lee C. K., Klopp R. C, Weindruch R., Prolla T.A. Gene expression profile of aging and its retardation by caloric restriction // Science. 1999. Vol. 285. P. 1390-1393.

 

Lee С. К., Weindruch R., Proila T.A. Gene-expression profile of the ageing brain in mice // Nature Genetics. 2000. Vol. 25. P. 294-297.

Lee C- H., Sawada N., Mochizuki Y. et al. Immortal epithelial cells of normal C3H mouse liver in culture: possible precursor populations for spontaneous hepa-tocellular carcinoma // Cancer Res. 1989. Vol. 49. P. 403-409.

 

Lee H.~ IV., Biasco M. A., Gottlieb G. J, etai. Essential role of mouse telomerase in highly proliferative organs // Nature. 1998. Vol. 392. P. 569-574,

 

Lee J., Cltan S. L., LaneM. A, Mattson M P. Phenformin suppresses calcium responses to glutamate and protects hippocampa] neurons against exictotoxicity // Exp. Neural. 2002. Vol. 175. P. 161-167.

 

Lehmann A. R. Ageing. DNA repair of radiation damage and carcinogenesis: Fact and fiction / Eds A. Likhachev, V. Anisimov. R. Montesano. Age-Related Factors in Carcinogenesis. IARC Sci Publ N 58. Lyon: 1ARC, 1985. P. 203-214.

 

Lengauer C, KinzlerK. W., Vogelstein 8. Genetic instabilities in human cancers// Nature.1998. Vol. 396. P. 643-649.

Lenz S. P., Izut S., Benediktsson H., Hart D.A. Lithium chloride enhances survival of NZB/W lupus mice: influence of melatonin and timing of treatment // Int. J. Immunopharmacol. 1995. Vol. 17. P. 581-592.

 

Lesnikov V. A., Pierpaoli W. Pineal crass-transplantation (old-to-young and vice versa) as evidence for an endogenous "aging clock" // Ann, N. Y. Acad. Sci. 1994. Vol. 719. P. 461-473.

 

Lewis M. PRELP, collagen, and a theary of Hutchinson-Gilford progeria // Ageing Res. Rev. 2003. Vol. 2. P. 95-105.

tJG. C, Ouyang H., Li X. el al. Ku70: a candidate tumor suppressor gene for murineTcelllymphoma//Mol. Cell. 1998. Vol.2. P. I-8.

US. C. LittdenbergerU., SikstrvmS. Aging cognition: from neuromodulation to representation //Trends Cogn. Sci. 2001. Vol. 5. P. 479-486.

Li X., Chen S., Wang Q. et ai A pineal regulatory element (PIRE) mediated transact! vat ion by the pineal/retina-specific transcription factor CRX // Proc, Natl. Acad. Sci. USA. 1998. Vol. 95. P. 1876-1881.

 

Liang S. В., Ohtsuki Y., Furihala M. et al. Sun-exposure- and aging-dependent p53 protein accumulation results in growth advantage for tumour cells in carcinogenesis of nonmelanocytic skin cancer// Virchows Arch. 1999. Vol. 434. P. 193-199.

 

Likhachev A. J. Effects of age on DNA repair in relation to carcinogenesis // Cancer and Aging / Eds A. Macieira-Coelho, B. Nordenskjold. Boca Raton: CRC Press. 1990. P. 97-108.

 

Lin Y. J., Serotide L, BenzerS. Extended life-span and stress resistance in the Drasophila mutant methuselah// Science. 1998. Vol. 28Z P. 943-946.

Link С D. Transgenic invertebrate models of age-associated neurodegenerative diseases//Mech.AgeingDev.2001. Vol. 122. P. 1630-1649.

Linnane A. W., Marzuki S., Ozawa Т., ТапакаМ. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases // Lancet. 1989. Vol. l.P. 642-645.

 

Lio D., Mario Pes C, Carru С et al. Association between the HLA DR alkies and longevity: a study in Sardinian population //Exp. Gerontol. 2003. Vol. 38. P. 313-318.

 

Liotta L A, Kohn E. С The microenvironment of the tumor-host interface // Nature. 2001. Vol. 411. P. 375-379.

Liptnan R. D. The prolongation of lifer a comparison of antioxidants and gero-protectors versus superoxide in human mitochondria // J. Gerontol. 1981. Vol. 36. P. 550-557.

 

Lipman R. D., Broiison R. Т., Wu D. et al. Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice // Mech. Ageing Dev. 1998. Vol. 103. P. 269-284.

 

Uptnan R. D., Dallai G. E., Bronson R. T. Effect of genotype and diet on age-related lesions in ad libitum fed and calorie-restricted F344, BN, and BNF3F] rats // J. Gerontol. Med. Sci. 1999. Vol. 54A. P. 478-491.

 

Upschitz D. A. Nutrition, aging and the immunohematopoietic system // Clin. Geriatr. Med. 1987. Vol. 3. P. 319-328.

Qungquht В., Berg S., Lanke J. et al. The effect of genetic factors for longevity: a comparison of identical and fraternal twins in the Swedish Twin Registry // J. Gerontol. A Biol. Sci. Med. Sci. 1998. Vol. 53. P. M441-M446.

 

Lokshin R. A, ZakeriZ. F. Programmed cell death: new thoughts and relevance to aging//J. Gerontol. 1990. Vol. 45. P. BI35-B140.

Longo V. D., Finch С. Е, Evolutionary medicine: from dwarf model systems to healthy centenarians?//Science. 2003. Vol. 299. P. 1342-1346.

Louhija J., Meittinen H. E., Kontula K. et al. Aging and genetic variations of plasma apolipoproteins: relative loss of the apolipoprotein E4 phenotype in centenarians// Arterioscler. Thromb. 1994. Vol. 14. P. 1084-1089.

 

UicasJ.A., AfanedS.A., Casey L M., MacdonaldP.C. Prevention of autoanti-body formation and prolonged survival in New Zealand black/New Zealand white F(l) mice fed dehydroepiandrosierone//J. Clin. Invest. 1985. Vol. 75. P. 2091-2093.

 

Uind J., TedescoP., Duke K. et al. Transcriptional profile of aging in С elegaes/f Curr. Biol. 2002. Vol. 12. P. 1566-1573.

Lup'ten S. J., de Leon M, de Sant't S. el al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits // Nature Neurosci. 1998. Vol. 1. P. 69-73.

 

Uitz W., O'Neil 8. C, Schebrov S. Europe's population at a turning point // Science. 2003. Vol. 299. P. 1991-1992.

Luzatto L The mechanisms of neoplastic trasformation // Eur. J. Cancer. 2001. Vol. 37. P. S1I4-5117-

LyD. H., UxkhartD. J., LernerR. A, ScfutltzP-G. Mitotk misregulation and human aging // Science. 2000. Vol. 287. P. 2486-2492.

Maciera-CoeUw A Genome reorganization through cell division, implications for aging of the organism and cancer development // Ann. N. Y. Acad. Sci. 1994. Vol. 719. P. 108-128.

 

Maciera-Coellw A. Neoplastic disease through the human life span // Bioge-rontology. 2001. Vol. 2. P. 179-192.

Mahler J. F., Stokes W,. Maim P. C. et al. Spontaneous lesions in aging FVB/N mice//Toxicol. Pathol. 1996. Vol. 24. P. 710-716.

Makeham W.M. On the Law of Mortality, and Construction of Annuity Tables. JIA, VIII. i860.

Malm O. J., Skaug O. E., Uegjaerde P. The effect of pinealectomy on bodily growth // Acta Endocr. 1959. Vol. 30. P. 22-28.

Maeson M. M., Green J, A., Driver H.E. Ethoxyquin alone induces preneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B(l)//Carcinogenesis. 1987. Vol. 8. P. 723-728.

 

Manned P. M., Mart D., Merati С et al. Gene polymorphism predicting high plasma levels of coagulation and fibrinolysis proteins: a study in centenarians// Arterioscler Thromb. Vase. Biol. 1997. Vol. 17. P. 755-759.

 

Marcotte R., Wang E, Repljcative senescence revisited // J. Cerontol. Biol. Sci. 2002. Vol. 57A. P. B257-B269.

Margolis J., Spradling A. Identification and behavior of epithelial stem cells in the Drosophila ovary //Development. 1995. Vol. 121.P.3797-3807.

Martin G. M. Syndromes of accelerated aging // Natl. Cancer Inst. Monograph. 198Z Vol. 60. P. 241-247.

Masoro E. J. Caloric restriction and ageing: an update // Exp. Gerontol. 2000. Vol. 35. P. 299-305.

Masoro E. J. Subfield history: Caloric restriction, slowing aging, and extending life // Science's SAGE KE, 2003, ns2 (26 February 2003). http://Sageke.sciencemag. org/cgi/ content/full/sageke; 2003/8/re2.

 

Masoro E. J., Austad S. N. The evolution of the antiaging action of dietary restriction: A hypothesis//J. Gerontol. A. Biol. Sci. Med. Sc. 1996. Vol.51. P. B387-B391.

 

Masoro ? ft. Use of rodents as models for the study of "normal aging": Conceptual and practical issues//Neu rob iol. Aging. 1991. VoL 12. P. 639-643.

Mastitani At., Nozak't Т., Nakawoto К. etai The reponse of Rarp knockout mice against DNA damaging agents//Mutar. Res. 2000. Vol. 462. P. 159-166.

Matlwn N. F, Malcolm D. S., Harrisingh M. C. et al. Lack of replicative senescence in normal rodent glia//Science. 2001. Vol. 291. P. 872-875.

Matolxa M, F., Cosgrove J. W., AtakJ. /?., RapoportS. I. Selective elevation of c-myc transcript levels in the liver of the aging Fischer-344 // Biochem. Biophys. Res. Comrnun. 1987. Vol. 147. P. 1-7.

 

Matsumoto A. M., Marck В. Т., Gruenewald D. A. el al. Aging and the neuroen-docrine regulation and body weight//Exp. Gerontol. 2000. Vol.35. P. 1251-1265.

 

Mattison J. Ames dwarf mice: a model for delayed aging // Успехи геронтол. 2000. Т. 4. С. 141-146.

Mattison J., Lane M. A, RothC.S., IngramD.K. Calorie restrction in rhesus monkeys // Exp. Gerontol. 2003. Vol. 38. P. 35-^6.

Mmtson M. P., Dime W., Lee J, et al. Progress in the development of caloric restriction mimetic dietary supplements // J, Anti-Aging Med. 2001. Vol.4. P. 225-232.

 

Mattson M. P., Duaii I V., Maswood N. How does the brain control lifespan? // Ageing Res. Rev. 2002. Vol. I. P. 155-165.

Mayer J., Marwah A., Weinmcvw J. Mitotic rate of gingival epithelium in two groups til. Invest. Dermatol. 1956. Vol. 27. P. 237-242.

Mayerhofer A., WeisJ., Banke A. et at. Effects of transgenes for human and bovine growth hormones on age-related changes in ovarian morphology in mice // Anat. Rec. 1990. Vol. 227. P. 175-186.

 

Mayersofat M. Pharmacokinetics in the elderly if Environ Health Perspectives Suppl 11.1994. Vol. 102. P. 119-124.

Mays-Hoopes L. L. Development, aging, and DNA methylation // Int Rev. Cy-tol. 1989. Vol. 114. P. 118-220.

McCall M. R., Frei li. Can antioxidant vitamins meterially reduce nxidative damage in humans? // Free Radical Biol. Med. 1999. Vol. 26. P. 1034-1053.

McCarty M. F. Longevity effect of chromium pi col mate - 'rejuvenation' of hy-pothalamic function? Medical Hypotheses. 1994. Vol. 3. P. 253-265.

МсСау С. М., Crowed M. F., Maynard LA. The effect of retarded growth upon the lenght of life span and upon the ultimate body size // J. Nutr. 1935. Vol. 10. P. 63-79.

 

McCleam G. E. Biomarkers of age and aging // Exp. Gerontol. 1997. Vol. 32. P. 87-94.

McCuliough K. D., CokmanW.B., Smith G.J., Grisiiam J. W. Age-dependent regulation of the tumorigenic potential of neoplastically transformed rat liver epithelial cells by the liver microenvironment // Cancer Res. 1994. Vol. 54. P. 3668-3671.

 

MedawarP. B. An Unsolved Problem of Biology. London: Lewis, 1952.

Mediavilla M. D., Cos S., Sanchez Barcelo E. J. Melatonin increases p53 and p21WAFl expression in MCF-7 human breast cancer cells in vitro// Life Sci. 1999. Vol.65. P.415-420.

 

Mecocci P., Polidari M. C, Troiano L. et at. Plasma antioxidants and longevity: a study on healthy centenarians//Free Radical Biol. Med. 2000. Vol. 28. P. 1243-1248.

 

Medina D., Shepherd F, Selenium-mediated inhibition of mouse mammary tu-morigenesis// Cancer Lett. 1980. Vol.8. P. 241-245.

Medvedev Z A. Age changes of chromatin // Mech. Ageing Dev. J984, Vol. 28. P. 139-154.

Medvedev Z. A. Possible role of repeated nucleotide sequences in DNA in the evolution of life spans of different cells // Nature. 1972. Vol. 237. P. 453-454.

 

Meeker H. C, Carp R. A Titres of murine leukemia virus are higher in brains of SAMP8 than SAMR1 mice//Neurobiol. Aging. 1997. Vol. 18. P. 543-547.

Meisatni R. Aging of the nervous system structural and biochemical changes // Physiological Basis of Aging and Geriatrics / Ed. P. S. Timiras, New York: Macmil-lan Publishing Co., 1988. P. 123-143.

 

ftfeliska C. J., Burke P. A., Bartke A., Jensen R. A. Inhibitory avoidance learning in tnmsgenic mice oven?xpre$sing the growth hormone gene // Neurobio. Learn, Med. 1997. Vol. 68. P. 1-12.

 

Meredith S., Jackson K., Dttdenhoeffer G. el al. Long-term supplementation with melatonin delays reproductive senescence in female rats, without an effect on number of primordial follicles// Exp. Gerontol. 2000. Vol. 35. P. 343-352.

 

Merry B. J., Holelian A M. Onset of puberty and duration of fertility in rats fed a restricted diet // J. Reprod. Fertil. 1979. Vol. 57. P. 253-259.

Meichnikoff E. Etudes sur la nature humaine: Essai de philosophie optimiste // Paris: Masson & C-ie, 1903. 399 p.

Michateki A. I., Yashin A. I, A probabilistic model for cancer prevalence estimation on mortality data // Models of Noncommunicable Diseases / Eds W. Morgen-stem, E. Chigan, R. Prokhorskas et al. Berlin; Heidelberg; New York: Springer, 1992. P. 45-53.

 

Miclmlski A. I., Jonlison T. K, CypserJ. R., Jashin A. I. Heating stress patterns in Caenorhabditis elegans longevity and survivorship // Biogerontology. 2000. Vol.5. P. 35-44.

 

Michel J. J, Xiong У, Human CUL-1, but not other cullin family members, selectively interacts with SKP1 tc form a complex with SKP2 and cyclin A // Cell Growth Differ. 1998. Vol. 9. P. 435-449.

 

Michishita ?., Nakabayashi К., Suzuki T, et al. 5-bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type qr species // J. Biochem. 1999. Vol. 125. P. 1052-1059.

 

Migliaccio E, Giorgio M., MeleS. et al. The p66shr adaptor protein controls oxidative stress response and life span in mammals // Nature. 1999. Vol.402. P, 309-313.

 

Mikhetson V. M. Replicative mosaicism might explain the seeming contradictions in the telomere theory of aging // Mcch. Ageing Dev. 2001. Vol. 122. P. 1361-1365.

 

Milter Ft, Aging and immune function // Fundamental Immunology. 4th ed. / Ed. W. E. Paul. Philadelphia: Uppincott; Raven Publ. 1999. P. 974-965.

Miller R. A. Gerontology as oncology //Cancer. 1991. Vol. 68. P. 2496-2501.

Miller R. A. Aging and cancer - another perspective // J. Gerontol. 1993. Vol. 48. P. B8-B9.

Miller D. В., Bartke A, O'Catlaghan J.P, Increased glial fibrillaiy acidic protein (GFAP) levels in the brains of transgenic mice expressing the bovine growth hormone (bGH) gene // Елр. Gerontol. 1995. Vol. 30. P. 383-400.

 

Miller R. A., Chirips C, Alchley W. Differential longevity in mouse stocks selected for early life growth trajectory // J. Gerontol. Biol. Sci. 2001. Vol. 55A. P. B455-B461.

 

Miller R. A., Harper J. M., Dysko R.C. etal. Linger life spans and delayed maturation in wild-derived mice // Exp. Biol. Med 2002. Vol. 227. P. 500-508.

 

Miskin ft, Masos T. Transgenic mice overexpressing urokinase-type plasmi-nogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity 111, Gerontol. Biol. Sci. 1997. Vol. 52A. P. B118-B124.

 

Miskin ft, Masos Т., Yahav S. et ai AlphaMUPA mice: a transgenic model for increased life span // Neurobiol. Aging. 1999. Vol. 20. P. 555-564.

Mitchel ft. E. J., McCann R.A, Skin tumor promotion by vitamin E in mice: amplification by ionizing radiation and Vitamin С // Cancer Detect. Prevent. 2003. Vol. 27. P. 102-108.

 

Mitsui A, Hwnuro J., Nak/тмга R. et al. Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span // Antioxid. Redox Signal. 2002. Vol. 4. P. 693-696.

 

Miyaishi O., Ando F., Matsuzawa K, et al. Cancer incidence in old age // Mech. Ageing Dev. 2000. Vol. 117. P. 47-55.

Miyamoto H., ManabeN., MitaniY. et al. Female reproductive properties and prenatal development of a senescence-accelerated mouse strain //J. Exp. Zool. 1995. Vol. 272. P. 116-122.

 

Mocchegiani ?., Santaretti L., Tibatdi A. et al. Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival//J. Neuroimmunology. 1998. Vol. 86. P. Ill-122.

 

Mockova K., Mnichova At., Kubatka P. et ai Mammary carcinogenesis induced in Wistar: han rats by the combination of ionizing radiation and dimethylbenz(a)anttiracene: prevention with melatonin // Neoplasma. 2000. Vol. 47. P. 227-229.

 

Modjancva E, A., Bocharava O. A., Malenkov A. G. A system of tissue integration and predisposition to spontaneous tumors //1ARC Sci. Publ. 1983.N5I.P. 135-142.

 

Moecftars D., Lorent К., De Strooper B. et al. Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neu-ronal degeneration and premature death in transgenic mice//EMBOJ. 1996. Vol. 15. P. 1265-1274.

 

Mohaghegh P., Hickson I. D. DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders // Hum. Mol. Genet. 2001. Vol.10. P. 741-746.

 

Monier F., Guespin-Michel J., FelenbokB. Incorporation of 5-bromo-2'deoxyu-ridine (BUdR) in Dictyostetimn discoldeum DNA // Exp. Cell Res. 1977. Vol. 107. P. 397-404.

 

Montesano R., Bartsch H., Vainio И. et al Long-Term and Short-Term Assays for Carcinogens: A Critical Appraisal. (IARC Sci. Publ. N 83). Lyon: IARC, 1986.

 

Montesano R., Hall J, Environmental causes of human cancers // Eur. J. Cancer. 2001.Suppl8. P. 67-87.

Moore M. A., Weber E., Thornton M., Bannasch P. Sex-dependent, tissue-specific opposing effects of dehydroepiandrosterone on initiation and modulation stages of liver and lung carcinogenesis induced by dihydroxy-di-n-propylnitrosamine in F344 rats // Carcinogenesis. 1988. Vol. 9. P. 1507-1509.

 

Morales A. J., Nodan J. J., Nelson J. C., Yen S. Effect of replacement dose of dehydroepiandrosterone in men and women of advancing age // J. Clin. Endocrinol. Metab.1994. Vol. 78. P. 1360-1367.

 

Morales C. P., Hole/ S. E., Ouetlette M. et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase // Nature Genetics. 1999. Vol. 21. P. 115-117.

 

Morgan W. W., Richardson A., Sharp Z ??., Waller C. A. Application of exoge-nously regulatable promoter systems to transgenic models for the study of aging // J. Gcrontol.: Biol. Sci. 1999. Vol. 54A. P. B30-B40.

 

Moriwaki S., Ray S., Tarone R. E. et al. The effect of donor age on the processing of UV-damaged DNA by cultured human cells: reduced DNA repir capacity and increased DNA mutability // Mutat. Res. 1996. Vol. 364. P. 117-123.

 

Morley A. A. The somatic mutation theory of ageing // Mutat. Res. 1995. Vol. 338. P. 19-23.

Moroy Т., Fischer P. E., Lee G. et at. High frequency of myelomonocytic tumors in aging E- mu L-myc transgenic mice // J. Exp. Med. 1992. Vol. 175. P. 313-322.

 

Morozov V. G., Khavinson V.Kh. Natural and synthetic thyrruc peptides as therapeutics for immune dysfunction // Int. J. lmmunopharmacol. 1997. Vol. 19. P. 501-505.

 

Morris C. D., Carson S. Routine vitamin supplementation to prevent cardiovascular disease: a summary of the evidence for the U.S. Preventive Services Task Force // Ann. Intern. Med. 2003. Vol. 139. P. 56-60.

 

Morris J. Z, Tissenbaum H. A., Rwkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans II Nature. 1996. Vol. 382. P. 536-539.

 

Morris S. H. The genetic toxicology of 5-bromodeoxyuridine in mammalian cells//Mutat. Res. 1991. Vol. 258. P. 161-188.

Moskovitz J., Bar-Noy S., Williams W. M. et al. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and life span in mammals // Proc. Natl. Acad. Sci. USA. 2001. Vol. 98. P. 12920-12925.

 

Mueller L. D., Rose M. R. Evolutionary theory predicts late-life mortality plateaus // Proc. Natl. Acad. Sci. USA. 1996. Vol. 93. P. 15249-15253.

Muskhelishvili L, TurturroA., HartR.W., James S. J. Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undegro apoptosis induced by dietary restriction // Am. J. Pathol. 1996. Vol. 149. P. 1585-1591.

 

Murphy С. Т., McCarroll S. A., Bargman С I. et al. Genes that act doqnstream of DAF-18 to influence the lifespan of Caenorftabditis elegans it Nature. 2003. Vol.424. P. 259-261.

 

Nabarra В., Casanova M., Paris D. et al. Premature thymic involution, observed at the ultrastructurai level, in two lineages of human-SOD-1 transgenic mice// Mech. Ageing Dev. 1997. Vol. 96. P. 59-73.

 

Nabeshima Y. Klotho: a fundamental regulator of aging // Ageing Res. Rev. 2002. Vol. 1. P. 627-638.

Nakachi K., Eguchi H., Imai K. Can teatime increase one's lifetime? // Ageing Res. Rev. 2003. Vol. 2. P. 1-10.

Napalkov N. P., Anis'tmov V. N., Ukfiachev A. J., Toiwtis L. 5-Bromodeoxyuri-dineinduced carcinogenesis and its modification by persistent estrus syndrome, unilateral nephrectomy, and X-trradiation in rats // Cancer Res. 1989. Vol. 49. P. 318-323.

 

NapoliC, Martin-Padural., deNigris F. etal. Deletion ofthep66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet // Proc. Natl. Acad. Sci. USA. 2003. Vol. 100. P. 2112-2116.

 

Neidle S., Parkinson G. Telomere maintnance as a target for anticancej: drug discovery// Nature Rev. Drug Discovery. 2002. Vol. 1. P. 383-393.

Nekhaeva E., Bodyak N. D., Kraytsberg Y. et al. Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues // Proc. Natl. Acad. Sci. USA 2002, Vol. 99. P. 5521-5526.

 

Nettesheim P., Topping D. C, Jamasbi R. Host and environmental factors enhancing carcinogenesis in the respiratory tract // Annu Rev. Pharmacol. Toxicol. 1981. Vol. 21. P. 133-163.

 

Neumann C. A., Krause D. S., Carman C. V. et al. Essential role for the peroxi-redoxin Prdxl in erythipcyte antioxjdant defence and tyrnour suppression // JNature. 2003. Vol. 424. P. 561-565.

 

Novoseltsev V. N., Carey J., LiedoP. et al. Anticipation of oxidative damage decelerates aging in virgin female medfliies: a hypothesis tested by statistical modeling // Exp. Gerontol. 2000. Vol. 35. P. 971^987.

 

Oakin-BendalumS., AnisY., Mr/., ZisappetN. Effects of long-term administration of melaionin and a putative antagonist on the ageing rat // NeuroReport. 1995. Vol. 6. P. 785-788.

 

Obukhova L K., Nakaidze N.Sh., Serebryany A. M. et at. Experimental analysis of the mechanism of ageing in Drosophiia melanogaster // Exp. Gerontol. 1979. Vol. 14. P. 335-342.

 

Odagiri У., Uchida И., Hosokawa M. et al. Accelerated accumulation of somatic mutations in the senescence-accelerated mouse // Nature Genet. 1998. Vol. 19. P. 116-117.

 

Oeppen J., Vaupel J. W. Broke limits to life expectancy // Science. 2002. Vol. 296. P. 1029-1031.

Oiihtsu Tsukada K., Tsukada Т., Isobe K. Accelerated development and aging of the immune system in p53-deficient mice//J. Immunol. 1999. Vol. 163. P. 1966-1972.

 

Ohno S., Nagai Y. Genes in multiple copies as the primary cause of aging // Eds D. Bergsma, D. E. Harrison, N. W. Paul. Genetic Effects of Aging. New York: Alan R. Uss. 1978. P. 501-514.

 

Oitshima M., Ward J. M., Wenk M. L. Preventive and enhancing effects of reti-noids on the development of naturally occuring tumors of skin, prostate gland, and endocrine pancreas in aged male ACI/segHapB.R rats // J. Natl, Сдпсег !nst.)985. Vol. 74. P. 517-524.

 

OtovnikovA. M. Telomeres, telomerase and aging: Origin of the theory // Exp. Gerontol. 1996. Vol. 31. P. 443-448.

Olshansky S. J., Carries B. A., Cassel С In search of Methuselah: estimating (he upper limits to human longevity //Science. 1990. Vol. 250. P. 634-640.

 

Ono Т., Uehara K, KurishitaA. et al. Biological significance of DNA methyla-tion in the aging process // Age & Aging. 1993. Vol. 22. P. 534-543.

Ono Т., Uefiara Y., Saito K, Ikeltata H. Mutation theory of aging, assessed in transgenic mice and knockout mice // Mech. Ageing Dev. 2002. Vol. 123. p. 1543-1552.

 

Ooka //., Shinkai T. Effects of chronic hyperthyroidism on the lifespanof the rat// Mech. Ageing Dev. 1986. Vol. 33. P. 275-282.

Ooka H., Segall P. E., Timiras P. S. Histology and survival in age-delayed low-tryptophan-fed rats // Mech. Ageing Dev. 1988. Vol. 43. P. 79-98.

Orentrekh N., BrindJ, L., RizerR. L, VogelmanJ. И. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentration throughout adulthood //J. Gin. Bndocrinol Metab. 1984. Vol. 59. P. 551-555.

 

Orrti. A. The evolutionary genetics of adaptation: a simulation study // Genet. Res. 1999. Vol. 74. P. 207-214.

OrrW. C, Sohal R.S. Extension of life-span by overexpresion of superoxide dismutase and catalase in Drosophila melanogaster II Science. 1994. Vol.263. P. 1128-1130.

 

Ouhtit A., Ueda M., Nakazawa M., Dutnaz N. et al. Quantitative detection of ultraviolet-specific p53 mutations in normal skin from Japanese patients // Cancer Epidemiol. Biomarkers Prev. 1997. Vol. 6. P. 433-438.

 

Owen M. R., Halestmp A. P. The mechanisms by which mild respiratory chain inhibitors inhibit hepatic neoglucogenesis // Biochim. Biophys. Acta. 1993. Vol. 1142. P. 11-22.

 

Oxenkmg G. F., Requintina P. J. Clorgyline effect on pineal tnelatonin biosynthesis in rats with lesioned suprachiasmatic nuclei // J. Neural Transm. Suppl. 1998. Vol. 52. P. 329-332.

 

Pakkenberg В., Pelvig D., MarnerL. et al. Aging and the human neocortex // Exp. Gerontol. 2003. Vol. 38. P. 95-99.

Pandi-Perumal S. R., Seil L K., Kayumov L et al. Senescence, sleep, and circa-dian rhythms//Ageing Res. Rev, 2002. Vol. 1. P. 559-604.

Paolisso C, Barbieri M., Rizzo M. Я et al. Low insulin resistance and preserved P-cell function contribute to human longevity but are not associated with TH-INS genes //Exp. Gerontol. 2001. Vol. 37. P. 149-156.

 

Papa S., Skuktchev V.P. Reactive oxygen species, mitochondria, apoptosis and aging // Molec. Cell. Biochem. 1997. Vol. 174. P. 305-319.

Paradis V., Yousse/K, Dargere D. et al Replicative senescence in normal liver, clironic hepatitis C, and hepatocellular carcinomas // Human Pathol. 2001. Vol. 32. P. 327-332.

 

Park J. W., Choi С. И., Kim M. S., Chung M. И. Oxidative status in senescence-accelerated mice// J. Gerontol. Biol. Sci. Med 1996. Vol. 51A. P. B337-345.

 

Parkes T. L, Elia A. J., Dickinson D. et al. Extension of Drosophila lifespan by overexpression of human SOD1 in motoneurons // Nature Genetics. 1998. Vol. 19. P. 171-174.

 

Parkin DM., BrayF.L, DevesaS.S. Cancer burden in the year 2000. The global picture // Eur. J. Cancer. 2001. Vol. 37. P. S4- S66.

Parsons P. A. Inherited stress resistance and longevity: a stress theory of ageing // Heredity. 1995. Vol. 75 (pt 2). P. 216-221.

Partridge L. Evolutionary theories of ageing applied to long-lived organisms // Exp. Gerontol. 2001. Vol. 36. P. 641-650.

Partridge L, Barton N. H. Optimality, mutation and the evolution of aging // Nature. 1993. Vol. 361. P. 305-311.

Pawelec C, Wagner W., Adibzadeh M. et al. T cell immunosenescence in vitro and in vivo // Exp. Gerontol. 1999. Vol. 34. P. 419-429.

Pedersen W. A., Mattson M. P. No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice //Brain Res. 1999. Vol. 833. P. П7-120.

 

Pegg A. E. Repair of O^-alkylguanine by alkyltransferases // Mutat. Res. 2000. Vol. 462. P. 83-100.

Penna T. J. P. A bit-string model for biological aging // J. Stat. Physics. 1995. Vol. 78. P. 1629-1633.

Penna T. J. P., Stauffer D. Efficient Monte-Carlo simulation of biological aging // Int. J. Modern Physics. 1995. Vol. 6. P. 233-239.

Pereira-Sntith O. M., Smith J. R. Genetic analysis of indi finite division in human cells. Identification of four complementary groups // Proc. Natl. Acad. Sci. USA. 1988. Vol. 85. P. 6042-6046.

 

Perkins S. N., Bursting S. D, Hatnes D. C. et at. Chemoprevention of spontaneous tunwrigenesis in nullyzygous p53-deficient mice by dehydroepiandrosterone and its analog 16-alpha-fluoro-5-androsten-17-one//Carcinogenesis. 1997. Vol. 18. P. 989-994.

 

Perls Т., AtpertL, FrettRC, Middle-aged mothers live longer//Nature. 1997. Vol. 389. P. 133.

Perls Т., Wager C, Bubrick E et al. Siblings of centenarians live longer // Lancet. 1998. Vol. 351. P. 1560.

Perls Т., Levenson R., Regan M., Риса A. What does it take to live to 100? // Mech. Ageing Dev. 2002. Vol. 123. P. 231-242.

Perls Т., Terry D. Genetics of exceptional longevity // Exp. Gerontol. 2003. Vol. 38. P. 725-730.

Petersen R. C. Aging, mild cognitive impairment, and Alzheimer's disease // Neural. Clin. 2000. Vol. 18. P. 789-806.

Peto J. Cancer epidemiology in the last century and the next decade // Nature. 2001. Vol. 411. P. 390-395.

Peto R., DollR. There is no such thing as aging // Br. J. Med. 1997. Vol. 315. P. 1030-1032.

Peto R., Roe F. J. C.,. Lee P. N. et al Cancer and ageing in mice and men // Br, J. Cancer. 1975. Vol. 3Z P. 411^26.

Peto R., Parish S. E., Cray R. G. There is no such thing as ageing and cancer is not related to it // Age-Related Factors in Careinogenesis / Eds. A. Likhachev, V. Anisimov, R. Moniesano (1ARC Sci. Publ. N 58). Lyon: [ARC, 1985. P. 43-53.

 

Phillips J. P., Campbells. D., MichaudD. et a!. Null mutation of copperfzinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity // Proc. Natl. Acad. Sci. USA.1989. Vol. 86. P. 2761-2765.

 

Piantanelli L, Rossolini C, Basso A. et at. Use of mathematical models of survivorship in the study of bioniark^rs of aging: the role of heterogeneity // Mech. Ageing Dev. 2001. Vol. 122. P.1461-1475.

 

Pierpaoli W., Maestroni G. J. M. Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its anti-aging effect //Immunol. Lett 1987. Vol. 16. P. 355-362.

 

Pierpaoli W., Regclson W. Pineal control of aging: effect of melatonin and pineal grafting on aging mice//Proc. Natl. Acad. Sci. USA. 1994. Vol. 91. P. 787-791.

 

Pierpaoli W., Dall'AraA., Pedrinis E, Regelson W. Pineal control of aging: the effect of melatonin and pineal grafting on the survival of older mice // Ann. N. Y. Acad. Sci. 1991. Vol. 621. P. 291-313.

 

Pittendrigh C. S., Daan S. Orcadian oscillations in rodents: a systematic increase of their frequency with age // Science. 1974. Vol. 186. P. 548-550.

Pittendrigh С S., Minis D. H. Orcadian systems: longevity as a function of cir-cadian resonance in Drosophila melanogaster // Proc. Natl. Acad. Sci. USA. 1972. Vol.69. P. 1537-1539.

 

Pleshakova O. V., Kutsyi M. P., Sukltarev S. A. et al. Study of protein carbonyls in subscellular fractions isolated from liver and spleen of old and gamma-irradiated rats // Mech. Ageing Dev. 1998. Vol. 103. P. 45-55.

 

Pletcher S. D., Neuhauser C. Biological aging - Criteria for modelling and a new mechanistic model // Int. J. Modem Physcis. 2000. Vol. 11. P. 525-546.

 

Ptoskonosova 1.1., Baranov V. I., GazievA. 1. PCR assay of DNA damage and repair at the gene level in brain and spleenof gamma-irradiated young and old rats // MutaL Res. 1999. Vol. 434. P. 109-117.

 

Polidori M. C, Spazzafutno L., Pez G. et al. Peripferal levels of enzymatic and non-enzymatic antioxidants in a large sample of Italian centenarians // Free Radical Biol. Med. 2002. Suppl. P. 109-110.

 

Pornpei F, Wilson R. Age distribution of cancer: the incidence turnover at old age. Human Ecol. Risk Assesment. 2001. Vol. 7. P. 1619-1650.

Pompei F., Poikanov M., Wilson R. Age distribution of cancer in mice: the incidence turnover at old age// Toxicol. Industr. Health. 2001. Vol. 17. P. 7-16.

 

Ponten J. Cell biology of precancer// Eur. J. Cancer. 2001. Vol. 37. P. S97-SU3.

Popovich I. C, Voitenkov О. В., Anisbnov V. N. et al. Effect of delta-sleep inducting pepti de-contain ing preparation Deltaran on biomarkers of aging, life span an spontaneous tumor incidence in female SHR mice // Mech. Ageing Dev. 2003. Vol. 124. P. 721-731.

 

Porta К A., Joun N. $., Nitta Я Т. Effect of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. I. Life span, serum biochemical parameters and pathological changes // Mpcb, Ageing Dev. 1980. Vol. 13. P. 1-39.

 

Potten C. S., Moms R. J. Epithelial cells in vivo // J. Cell Sci. Suppl. 1988. Vol. 10. P. 45-62.

Potten M., Loeffler M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt//Development. 1990. Vol. 110. P. 1001-1020.

 

Pour P., AithoffJ., Satinasi S. Z., Stepan K. Spontaneous tumors and common diseases in three types of hamsters. Hi. Natl. Cancer Inst. 1979. Vol. 63. P. 797.

 

Provincial! M., FabrisN. Role of pituitary-thyroid axis on basal and lymphokine-induced NK cell activity in aging // Jnt J. Neurosci. 1990. Vol. 51. P. 373-375.

 

Qin X., Zhang S., Matsukuma S. et al. Protection against malignant progression of spontaneously developing liver tumors in transgenic mice expressing O'-methylguanine-DNA methyltransferase//Jpn. J. Cancer Res. 2000. Vol. 91. P. 1085-1089.

 

Rao M.S. Dehydroepiandrasterone- induced hepatocarcinogenesis in the rat // Int. J. Oncol. 1997. Vol. 11. P. 920.

Rahman K, Garlic and aging: new isights into an old remedy // Ageing Res. Rev. 2003. Vol. 2. P. 39-56.

Reddel R. R. The role of senescence and immortalization in carcinogenesis // Carcinogenesis. 2000. Vol. 21. P. 477-484.

Reiter R. J. The pineal gland and melatonin in relation to aging*. A summary of the theories and of the data //Exp. Cerontol. 1995. Vol. 30. P. 199-212.

 

Reiicr R. J. Experimental observations related to the utility of melatonin in attenuating age-related diseases// Успехи геронтол. 1999. Т. 3. С. 121-132.

 

Reiter R. J., Richardson B. A., Johnson L Y. et at. Pineal melatonin rhythm: reduction in aging Syrian hamsters // Science. 1980. Vol. 210. P. 1372-1373.

 

Reiter R. J., Tan D. X., Allegra M. Melatonin: reducing molecular pathology and dysfunction due to free radicals and associated reactant // Neuroendocr. Lett 2002. Vol. 23, Suppl. l.P. 3-8.

 

Reher R. J., Tan D. - X., Kim S.J.etaL Augmentation of indited of oxidative damage in life-long melatonin-deficient rats // Mech. Ageing Dev. 1999. Vol. 110. P. 157-173.

 

Reuber M. D., Glover E. L Hyperplastic and early neoplastic lesions of the liver in Buffalo strain rats of various ages given subcutaneous carbon tetrachloride // J. Nail. Cancer Inst. 1967. Vol. 38. P. 891-897.

 

Revskoy S., Redei E. Decreased in vitro sensitivity to dexamethasone in cortko-tropes from middle-age rats // Exp. Gerontol. 2000. Vol. 35. P. 237-242.

 

Reya Т., Morrison S. J., Clarke M. F., Weissman 1. L Stem cells, cancer, and cancer stem cells// Nature. 2001. Vol.414. P. 105-111.

Reznick D. N. Cost of reproduction: an evaluation of empirical evidence // Oi-cos. 1995. Vol. 44. P. 257.

Rha S. Y. et al. Changes of lelomerase and telomere length in paricd normal and cancer tissues ofbreast//Int. J.Oncol. 1999. Vol. 15. P. 839-845.

Richardson B. Impact of aging on DNA methylation // Ageing Res. Rev. 2003. Vol. 2. P. 245-261.

Richardson A., Butler J. A, Rutherford M. S. et al. Effect of age and dietary restriction on the expression of O2v-globulin // J. Biol. Chem. 1987. Vo)- 262, P. 12821-12825.

 

RiMefs R. E., Sckeuerlein A., Cohen A. Age-related patterns of fertility in captive populations of birds and mammals //Exp. Gerontol. 2003. Vol. 38. P. 741-745.

 

Ries L. A. G., Eisner M. P., Kosary C. L. et al. (Eds). SEER Cancer Statistics Review, 1973-1998, National Cancer Institute. Bethesda, MD, 2001.

Riggs J. E. Aging and mortality: manifestations of increased information entropy of the genome//Mech. Ageing Dev. 1993. Vol.66. P. 249-256.

Rinehart C. A., Torii V. R. Aging and cancer; The role of stromal interactions with epithelial cells //Mol. Carcinogenesis. 1997. Vol. 18. P. 187-192.

Risch N., Reich E. W., WishnickM. M., McCarthy J. G. Spontaneous mutation and parental age in humans//Am J. Human Genet. 1987. Vol. 41. P. 218-248.

Robine J.M., Aliard M. The oldest human // Science. 1998. Vol.279. P. 1834-1835.

Robine J. M., Coumil A., Menon N., Allan! M. Have centenarians had younger parents than the others? // Exp. Gerontol. 2000. Vol. 38. P. 361-365.

Robine J. M., Saito Y., Jagger С The emergence of exltemely old people: the case of Japan // Exp. Gerontol. 2003. Vol. 38. P. 735-739.

Rodin S, N., Rodin A. S. Strand asymmetry of CpG transitions as indicators of Gl phase-dependent origin of multiple tumorigentc p53 mutations in stem cells // Proc. Natl. Acad. Sci. USA. 1998. Vol. 95. P. 11927-11932.

 

Roe F. J. C., Carter R. L., Mitchley R. et aL On the persistence of tumor initiation and the acceleration of tumor progression in mouse skin tumorigenesis // Int. J, Cancer. 1972. Vol. 9. P. 264-273.

 

Rogers A., Rogers R. G., Branch L. G. A multistate analysis of active life expectancy// Public Health Reports. 1989. Vol. 104. P, 222-226.

Rogina В., Reenan R. A., NilsenS.P., HetfandS.I. Extended life-span conferred by cotransporter gene mutation in Drosophila t! Science. 2000. Vol. 290. P. 2137-2140.

 

Rohme D. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo // Proc. Natl. Acad. Sci. USA. 1981. Vol. 78. P. 5009-5013.

 

Rollo C. D., Carlson J., Sawada M. Accelerated aging of giant transgenic mice is associated with elevated free radical processes // Can. J. Zool. 1996. Vol. 74. P. 606-620.

 

Romanov S. R., Kozflkiewicz B. K., Hoist C. R. et al. Normal human mammary epithelial cells spontaneously escape senescence and aquire genomic changes // Nature. 2001. Vol. 409. P. 633-^37.

 

Rose M.R. Evolutionary Biology of Aging. N.Y.: Oxford Univ. Press, 1991.221 p.

Ross M. H., Lustbader E. D., Bras G. Body weight, dietary practices, and tumor susceptibility in the rat//J. Natl. Cancer Inst. 1983. Vol. 71. P. 1041-1046.

 

Ross О. A., McCormick R, Curran M. D. et al. Mitochondria] DNA polymorphism: its role in longevity of the Irish population // Exp. Gerontol. 2001. Vol. 36. P. 1161-1178.

 

Rossmamth W. G. Neuroendocrinology of aging in the reproductive system: go-nadotropin secretion as an example // Follicular Gowrth, Ovulation an Fertilization; Molecular and Clinical Basis / Eds. A. Kumar, A, K, Mukbcpadhayay. New Pehli: Narosa Publ. House, 2001. P. 15-25.

 

Roth G. S., Ingram D. K., Black A., Lane M. A Effect of reduced energy intake on the biology of aging: the primate model // Eur. J. Clin. Nutr. 2000. Vol. 54, Suppl. 3. P. SIS-S20.

 

Roth G. S., Ingram D. K., Cutler R C, Lane M. A. Biological effects of caloric restriction in primates //Успехи геронтол. 1999.T.3.C 116-120.

Roth G. S., Joseph J. A. Peculiarities of the effect of hormones and transmitters during aging: Modulation of changes in dopamin action // Gerontology. 1988. Vol. 34. P. 22-28.

 

Roth G. S., Lane M. A., Ingram D. K. et al. Biomarkers of caloric restriction may predict longevity in humans //Science. 2002. Vol. 297. P. 811.

Ruan H., Tang X. D., Chen M.-L et al. High quality life extension by the enzyme peptide methionine si If oxide reductase // Proc. Natl. Acad. Sci. USA. 2002. Vol. 99. P. 2748-2753.

 

Roy A. K., Oh Т., Rivera O. et al. Impact of transcriptional regulation on aging and senescence // Ageing Res. Rev. 2002. Vol. 1. P. 367-380.

Rubin H. Cell aging in vivo and in vitro // Mech. Ageing Dev. 1ЭД7. Vol. 98. P. 1-35.

Rubin H. Selected cell and selective rracroenvironment in neoplastk development // Cancer Res. 2001. Vol. 61. P.799-"07.

Rubin И. The disparity between human cell senescence in vitro and lifelong replication in vivo // Nature Biotechnol. 2002. VA. 20. P. 675-6SI.

Rudman D., Feller A. G., Nagraj H. S. etal. Effect of human growth hormone in men over 60 years old // The New Engl. J. Med. 1990. Vol. 323. P. 1-6.

Rudolph K. L, Chang S., Lee H. W. et at. Longevity, stress response, and cancer in aging telomerase-deficient mice // Cell. 1999. Vol. 96. P. 701-712.

Ruffolo P. R., Ferm V.H. The embryonal and teratogenic effects of 5-bromode-oxyurudine in the pregnant hamster// Lab. Invest. 1985. Vol. 14. P. 1547-1553.

 

Rutten B. P. F., Korr H., Steinbusch H. W. M., Schmitz С The aging brain:L less neurons could be better// Mech. Ageing Dev. 2003. Vol. 124. P. 349-355.

 

Sacher G. A. Life table modification and life prolongation / Eds С. Е. Finch, L. Hayflick. Handbook Qf the Biology of Aging. N- Y.: Van Nostrand Reinhold, 1977. P. 582-638.

 

Saito Y., Nakamura Т., Ohyama Y. et at. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome // Biochem, Bio-phys. Res. Commun. 2000. Vol. 276. P. 767-772.

 

Salvoti S., Bonafe M., Capri M. et al. Mitochondria, aging and longevity - a new perspective // FEBS Lett. 2001. Vol. 492. P. 9-13.

Samis И. V., FalzoneJ. A., WulffV. J. HJ-Thyrrudine incorporation and mitotic activity in liver of rats qf various ages // Gerontologia 1966. Vol. 12. P. 79-88.

 

Samper Е., Ftores J. M., Btasco M. A. Restoration of telomerasc activity rescues chromosomal instability and premature aging in Tere4- mice with short telorneres // EMBO Reports. 2001. Vol. 2, P. 800-807.

 

Saretzki C, Sitte N., Merkel V. et al. Telomere shortening triggers a p53-de-pendent cell cycle arrest via accumulation of G-ricb single stranded DNA fragments // Oncogene. 1999. Vol. 19. P. 5148-5158.

 

Saretzki C, von Zglinicld T. Replieative aging, telomere, and oxidative stress // Ann. N.Y. Acad. Sci. 2002. Vol. 959. P. 24-29.

Sato S., Taketoml M., Nakajima M. et al. Effect of aging on spontaneous micro-nucleus frequencies in peripheral blood of nine mouse strains // MutaL Res. 1995. Vol. 338. P. 51-57.

 

Schachter F., Faure-DelanefL, Guenot F. et al. Genetic associations with human longevity at the APOE and ACE loci // Nature Genetics. 1994. Vol. 6. P. 29-32.

 

SchererS. S., Xu Y. Т., Nelles E. et al. Ccmnexin32-null mice develop demyeli-nating peripheral neuropathy // Glia. 1998. Vol. 24. P. 8-20.

Schtessinger D., Van Zant G. Does functional depletion of stem cells drive aging?//Mech. Ageing Dev. 2001. Vol. 122.P. 1537-1553.

Schmitt C. A. Senescence, apoptosis and therapy - cutting the lifelines of cancer // Nat. Rev. Cancer. 2003. Vol. 3. P. 286-295.

Schntitz C, Axmacher В., ZunkerU., Korrti. Age-related changes of DNA repair and rrutochondrial DNA synthesis in the mouse brain // Acta Neuropathol. 1999. Vol. 97. P. 71-81.

 

Schwartz M. W., Woods S. C, Porte D. et al. Central nervous system control control of food intake // Nature. 2000. Vol. 404. P. 661-671.

Schrauzer G. N., Ishmael D. Effect of selenium and of arsenic on the genesis of spontaneous mammary tumors in inbred C3H mice // Ann. Clin. Lab. Sci. 1974. Vol. 4. P. 441-447.

 

Schrlner S. K, Ogburn С E., Smith A. C. et at. Levels of DNA damage are unaltered in mice overexpressing human catalase in nuclei // Free Radical Biol. Med. 2000. Vol. 29. P. 664-673.

 

Schroeder H. A., Mitchener M. Selenium and tellurium in rats: effect on growth, survival and tumors //J. Nutr. 1971. Vol. 101. P. 1531-1540.

Schulz-Aellen M,- F. Aging and Human Longevity. Boston: Birkhauser, 1997. 283 p.

Schwartz A. G., Whitcontb J. M., Nyce J. W. et at. Dehydroepiandrosterone and structural analogs: a new class of cancer chemopreven(ive agents // Adv. Cancer Res. 1988. Vol. 51. P. 391-424.

 

Schwartz M. W., Woods S. C., Porte D. et al. Central nervous system control of food intake // Nature. 2000. Vol. 404. P. 661-671.

Scorrano L. Oakes S. A., Opferman J. T. et al. BAX and ВАК regulation of en-doplasmic reticulum Ca2+: a control point for apoptosis // Science. 2003. Vol. 300. P. 135-139.

 

Segall P. E., Timiras P.S. Pathc-physiologic findings after chronic tryptophan deficiency in rats: a model for delayed growth and aging // Mech. Ageing Dev, 1976. Vol. 5. P. 109-124.

 

Sell D. R, Lane M. A, Jonhson W. A, et al. Longevity and the genetic determination of collagen glycosidation kinetics in mammalian senescence // Proc. Natl. Acad. Sci. USA. 1996. Vol. 93. P. 485-490.

 

Seluanov A., Corbunova V., FalcovitzA. et al. Change of the death pathway in senescent human fibrobalsts in response to DNA amage is caused by an inability to stabilize p53 // Mol. Cell Biol. 2001. Vol. 21. P. 1552-1564.

 

Setye H. The evolution of the stress concept // Am. Sci. 1973. Vol. 61. P. 692-699.

Seong K. H., Ogashiva Т., Matsuo T. et at. Application of the gene search system to a screen for longevity genes in Drosohpila II Biogerontology, 2001. Vol. 2. P. 209-217.

 

Serrano M., Blasco M. A. Putting the stress on senescence // Curr. Opin. Cell Biol. 2001. Vol. 13. P. 748-753.

Serrano M., Lin A. W., McGurmch M. E. et al. Oncogenic ras provokes premature cell senescence associated wfth accumulation of p53 and pl6 1NK4a, Cell. 1997. Vol. 88. P. 593-602.

 

Severino J., Allen R. C, Balm S. et at. Is beta-galactosidase staining a marker of senescence in vitro and in vivo? // Exp. Cell Res. 20П0. Vol. 257. P. 162-171.

 

Shanley B. P., Kirkwood T. B. L. Calorie restriction and aging: a life history analysis//Evolution. 2001. Vol. 54. P. 740-750.

Sfiarkey F. E, Fogh J. Incidence and pathological features of spontaneous tumors in athymic nude mice//Cancer Res. 1979. Vol. 39. P. 833-839.

Shay J. W., Pereira-Smith O. M., Wright W, R. A role of both Rb and p53 in the regulation of human cellular senescence //Exp. Cell Res. 1991. Vol. 196. P. 33-39.

 

Shay J. W., Wright W.E, Telomere and telomerase: implications for cancer and aging//Radiat. Rees. 2001. Vol. 155. P. 188-193.

Shay J, W., Wright W. E., Werbin H. Loss of telomeric DNA during aging may predispose cells to cancer (review) // Int. J. Oncology. 1993. Vol. 3. P. 559-563.

 

Shelton D. N., Chang E., Whittier P. S. et al. Microaijay analysis of repiicative senescence//Current Biology. 1999. Vol. 9- P- 939-945.

Shepherd J. C, WalldorfU., Hug P., Cehring W. J. Fruit flies with additional expression of the elongation factor EF-1 live longer // Proc. Ant. Acad. Sci. USA. 1989. Vol. 86. P. 7520-7521.

 

Shigenaga M. K., Hogen T. M., Ames B. N. Oxidative damage and mitochondrial decay in aging//Proc. Natl. Acad. Sci. 1994. Vol. 91. P. 10771-10778.

Shimokawa /., Higami Y., Tsuchiya T. et al. Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction // FASED S. 2003. Vol. 17. P. 1108-1109.

 

Shimokawa I., Higanti Y., Utsuyama M. et al. Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model // Am. J. Pathol. 2002. Vol. 160. P. 2259-2265.

 

Shira M-lidaT., lidaA., NabeshitnaY, et al. Improvement of multiple patho-physiological phenotypes of klotho (kt/kl) mice by adenovirus-mediated expression of the klotho gene // J. Gene Med. 2000. Vol. 2. P. 233-242.

 

Shisa H., Kojima A., Hiai И. Accelerating effect of nude gene heterozygocity on spontaneous AKR thymic lymphomagenesis // Jpn. J. Cancer Res. 1986. Vol. 77. P. 568-571.

 

Shop M., Kwarabayashi Т., Sato M. et al. Age-related amyloid beta protein accumulation induces cellular death and macrophage activation in transgenic mice // J, Pathol. 2000. Vol. 191. P. 93-101.

 

Siegel R. M., Katsumata M., Mvyashita T. et al. Inhibition of thymocyte apop-tosis and negative antigenic selection in bcl-2 transgenic mice // Proc. Natl. Acad. Sci. USA. 1992. Vol. 89. P. 7003-7007.

 

Simon A. F., Shih C, Mack A., Benzer S. Steroid control of longevity in Drvso-phila melanogsterlf Science. 2003. Vol. 2000. P. 1407-1410.

Simpson A. J. G. A natural somatic mutation frequency and human cancino-genesis// Adv. Cancer Res. 1997. Vol. 71. P. 209-240.

Singer B., Grmberger D. Molecular Biology of Mutagens and Carcinogens. New York: Plenum Press, 1983.

Skulachev V. P. Cytochrome с in the apoptotic and antioxidant cascades // FEBS Lett. 1998. Vol. 423. P. 275-280.

Skulachev V, P. Mitochondria! physiology and pathology; concepts of programmed death of organelles, cells and organisms // Mol. Aspects Med 1999. Vol. 20. P. 139-184.

 

Skulachev V. P. The рбб*1 protein: A mediator of the programmed death of an organism//IUBMB Life. 2000. Vol.49. P. 177-180.

Skulachev V. P. The programmed death phenomena, aging, and the Samurai law of biology // Exp. Gerontol. 2001. Vol. 36. P. 995-1024.

Skulachev V. P. Programmes death phenomena: from organelle to organism // Ann. N.Y. Acad. Sci. 2O02. Vol. 959. P. 214-237.

Smith B. A., Edwards M. S., Ballacliey В. Е. et at. Body weight and longevity in genetically obese and non-obese mice fed fat-modified diets // Growth Pev. Aging. 1991. Vol. 55. P. 81-89.

 

Smith D. B. D., Tlwmpson L W., Michatewski H. J. Average evoked potential research in adult aging-status and prospects // Aging in the 1980s. Washington, DC: Amer. Psychological Association, 1980. P. 135-151.

 

Smith G. S., Watford Я L, Mickey H. Й. Ufespan and incidence of cancer and other diseases in selected long-lived inbred mice and their Fl hybrids // J. Natl. Cancer Inst. 1973. Vol. 50. P. 1195-1213.

 

Smith J. R., Pereira-Smith О. М. Replicative senescence: implications for in vivo aging and tumor suppression// Science. 1996. Vol. 273. P. 63-67.

Snibson K. J., Bhatha, P. S., Hardy С L High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice//Liver. 1999. Vol. 19. p. 242-252.

 

SohalR. S. Role of oxidatve stress and protein oxidation in the aging process // Free Radical Biol. Med. 2O02. Vol. 33. P. 37-44.

SohalR. S., WeindruchR. Oxidative stress, caloric restriction, and aging // Science. 1996. Vol. 273. P. 59-63.

Sonntag W. E., Lynch C, D., Cefitlu W. T. et al. Pleitropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restrictd animals // J. Gerontol. Biol. Sci. 1999. Vol. 54A. P. B521-B538.

 

Sorensen А В., Weinert F.E., SltenvdLR. Human Development andihe Life Course: Multidisciplinary Perspectives. Hillsdale: Lawrence Eribaum Assoc, 1986. 245 р.

 

Spadling J. W., French J. E-, Stasiewicz S. et al. Responses of transgenic mouse lines p53(4/-) and Tg.AC to agents tested in conventional carcinogenicity bioassays // Toxicol. Sci. 2000. Vol. 53. R 213-223.

 

Status J. Standardized nomenclature for inbred strains of mice: seventh listing // Cancer Res. 1980. Vol. 40. P. 2083-2128.

Staujfer D. Monte-Carlo simulation for biological aging // Brazil. J. Physcics. 1994. Vol. 24. P. 900^906.

Steger Я W., Bartke A., Cecim M. Premature aging in transgenic mice exressing growth hormone genes//J. Repr. Fertil. Supp]. 1993. Vol.46. P. 61-75.

Stenback F., Peto R., Shubik P. Initiation and promotion at different ages and doses in 2200 mice. III. Linear extrapolation from high doses may underestimate low-dose tumour risks//Br.J. Cancer. 1981. Vol. 44. P. 24-34.

 

Stenback F., Weisburger J. H., Williams G. M. Effect of lifetime administration of dimethylaminoethanol on longevity, aging changes, and cryptogenic neoplasms in C3H mice // Mech. Ageing Dev. 1988. Vol. 42. P. 129-138.

 

Stevens R. C, Wilson B. W., Anderson L E. The Melatonin Hypothesis, Breast Cancer and Use of Electric Power. Columbus: В at tele Press, 1997.

Stevenson L. E, Fmcjetton A. R. Constitutively tyrosine phosphorylated p52Shc in breast cancer cells: correlation with ErbB2 and p66Sch expression // Breast Cancer Res. Treat. 1998. Vol. 49. P. 119-128.

 

Stewart S. A., Weinberg R. A. Senescence: does it all happen at the ends? // Qn-cogene. 2O02. Vol. 21. P. 627-630.

Stocktin E, Botteri F., Groner B, An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice // J. Cell. Biol. 1993. Vol. 122. P. 199-208.

 

Stokkan K. A., ReiterR, J., Nonaka K. O. et al. Food restriction retards ageing of the pineal gland // Brain Res. 1991. Vol. 545. P. 66-72.

StorerJ. B. Longevity and gross pathology at death in 22 inbred mouse strains // J. Gerontol. 1966. Vol. 21. P. 404-^09.

Strehler B. L, MitdvonA.S. General theory of mortality and aging // Science. 1960. Vol. 132. P.14-21.

Stuart G. R., Oda Y., de BoerJ. C., GlicktnanB. W. No change in spontaneous mutation frequency or specificity in dietary restricted mice // Carcinogenesis. 2000. Vol. 21. P. 317-319.

 

Stutman O. Spontaneous tumors in nude mice: effect of the viable yellow gene // Exp. Cell. Biol. 1979. Vol. 47. P. 129-135.

Subramanian A, Kothari L. Melatonin, a supresor of spontaneous murine mammary tumors//J. Pineal Res. 1991. Vol. 10. P. 136-140.

Sugawara O., OshimuraM., KoiM. et al. Induction of cellular senescence in immortalized cells by human chromosome I // Science. 1990. Vol. 247. p. 707-710.

 

Sugimum T., Sakumi M., Hayahi N. et al. Age-related changes of the prostate gland in the senescence-accelerated mouse//Prostate, 1994. Vol. 24. P. 24-32.

 

Sukata Т., Ozaki K., Uwagara S. et al. Organ-specific, carcinogen-induced increases in cell proliferation in p53-defecient mice // Cancer Res. 2000. Vol. 60. p. 74-79.

 

Summerhayes /. С, Franks L. M. Effect of donor age on neoplastic transformation of adult bladder epithelium in vitro // J. Natl. Cancer. Inst. 1979. Vol.62. P, 1017-1023.

 

Sun F. K, Lin X., Mao LZ. et al. Neuroprotection by melatonin against ischemic neuronal injury associated with modulation of DNA damage and repair in the rat following a transient cerebral ischemia // J. Pineal Res. 2002. Vol. 33. P. 48-56.

 

Sim J., Tower J. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophtlft melanogaster flies //Mol. Cell. Biol. 1999. Vol. 19. P. 216-228.

 

Suzuki H., Gabriehon E., Clien W. et al. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer // Nature Genet. 2002. Vol. 31. P. 141-149.

 

Suzuki Т., iwataT., MinagawaS. et al. Large-scale screening for senescence-associated genes with 5-bromodeoxyuridine and immortal cell lines. First Conference on Functional Cenomics of Aging. April 24-27,2002. Seville, Spain, 2002. P. 12.

 

Suzuki T, Mhiagawa S., Michtshiia E. et al. Induction of senescence-associated genes by 5-brQmodeoxyuridj.ne in HeLa cells // Цхр. Gerontol. 2001. Vol. 36. p. 465-174.

 

Suzuki Т., Yagunuma M., Oisht T. et al. 5-Bromodeoxyuridine suppresses position effect variegation of transgenes in HeLa cells//Exp. Cell Res. 2001a. Vol. 266. P. 53-63.

 

Szyf M. Targeting DNA methylation in cancer//Ageing Res. Rev. 2003. Vol.2, p. 299-328.

Takaliashi M., Kokubo Т., Furukawa F. et al. Inhibition of spontaneouss leuke-mis in F-344 rats by tetramethylthiuram disulfide (Thiram) // Gann. 1983. Vol. 74. P. 810-813.

 

TakahashiM., Nishimura S., Miyajima K. et al. Time-dependent promotion activity of I7p-estradiol on uterine carcinogenesis in mice initiated with N-ethyl-N-nitrosourea // Cancer Lett. 2001. Vol. 165. P. 123-130.

 

Takahashi S., Okazaki K., Kawashima S. Mitotic activity of prolactin cells in the piuitary glands of male and female rats of different ages // Cell Tissue Res. 1984. Vol. 235. P. 497-502.

 

Takeda T. Senescence-accelerated mouse (SAM): a biogerontological resourse in aging research//Neurobiol. Aging. 1999. Vol. 20. P. 105-110.

Takeda Т., Matushtta Т., Киюгипя M. et al. Pathobicdogy of the senescence-accelerated mouse (SAM) // Exp. Gerontol. 1997. Vol. 32. P. 117-127.

Takubo K., izumiyarna-Shimomum N., Honma N. et al. Telomere length are characteristic in each human individual // Exp. Gerontol. 2002. Vol. 37. P. 523-531.

 

Takubo K., Nakamura K., Izymiyama N. et al. Telomere shortening with aging in human liver//J. Gerontol. A Biol. Sci. 2000. Vol. 55. P. B533-B536.

Tan D. X., Chen L D., Poeggeler B. et al. Melatonin: A potent, endogenous hy-droxyl radical scavanger//Endocrine J. 1993. Vol. 1.P.57-60.

Tanaka M., Cong J. S., Zhang J. et al. Mitochondrial genotype associated with longevity// Lancet.1998. Vol. 351. P. 185-186.

Tang D. C. Tokumoto Y. M, Apperly J. A. et at. Lack of replicative senescence in cultured rat oligodendrocyte precursor cell// Science. 2001. Vol.291. P. 868-871.

 

Tatar M., BartkeA., АтеЫА. The endocrine regulation of aging by insulin-like signals// Science. 2003. Vol. 299. P. 1346-1351.

Tatar M., Kkazeaelt A. A., Cursinger J. W. Chaperoning extended life // Nature. 1997. Vol. 390. P. 30.

Tatar M., KopetmanA., Epstein D. et at. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroenodcrine function // Science. 2001. Vol. 292. P. 107-110.

 

Tauchi H., Sato Т., Watanabe T Japanese Centenarians: Medical Ргьеагсп for the Final Stages of Human Aging. Aichi, Japan: Aichi Medical University, 1999.200 p.

 

Tavotoni N., Inoue H. Cellular aging is a critical determinant of primary cell resistance to v-src transformation //J. Virol. 1997. Vol.71. P. 237-247.

 

TemmeA., BuchmannA., GabrielИ. D. et at. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin 32 // Curr. Biol. 1997. Vol. 7. P. 713-716.

 

Teramoto S., Fukuehi Y., Uejima Y. et at. Influences of chronic tobacco smoke inhalation on aging and oxidant-antioxidant balance in the senescent-accelerated mouse (SAM)-P/2 // Exp. Geroruol. 1993. Vol. 28. P. 87-95.

 

Teriokhin A. T. Evolutionary optimal age schedule of repair computer modelling of energy partition between current and future survival and reproduction // Evol. Ecol. 1998. Vol.12. P. 291-307.

 

Thatcher A. R., KamistoV., VaupelJ. W. The Force of Mortality at Ages 80 to 120. Odense: Odense Univ Press, 1998.

The Aging Factor in Health and Disease. Workshop Report. New York: International Longevity Center, USA, Ltd., 1999. 24 p.

Thomas J. N., Smith-Sonnebom J. Supplemental melatonin increases clonal lifespan \ntbtyrAcaazriParameeuun1etmurelia//\. Pineal Res. 1997. Vol. 23. P. 123-130.

 

Thotnpson J. S., Robbins J., Cooper J. K. Nutrition and immune function in the geriatric population // Clin. Geriatr. Med. 1987. Vol. 3. P. 309-317.

Thompson T. A., HaagJ.D., Gould M. N. ras gene mutations are absent in NMU-induced mammary carcinomas from aging rat // Carcinogenesis. 2000. Vol. 21. P. 1917-1922.

 

Tinker A. iht social implications of an ageing population//Mech. Ageing Dev. 2002. Vol. 123. P. 729-735.

TominagaS. Major avoidable risk factors of cancer // Cancer Lett. 1999. Vol. 143. P. S19-23.

Totter J. R. Spontaneous cancer and its possible relationship to oxygen metabolism //Proc. Natl. Acad. Sci. USA. 1980. Vol. 77. P. 1763-1767.

Touitou Y. Human aging and melatonin. Clinical relevance // Exp. Gerontol. 2001. Vol. 36. P- 1083-1100.

Touitou K, Fevre M., Lagoguey M. et at Age and mental health related cir-cadian rhythms of plasma melatonin, prolactin, luteinizing hormone and follicle stimulating hormone // J. Endocr. 1981, Vol. 91. P. 467-475.

 

Toussaint O., Remade J., DierickJ.-F. etal Approach of evolutionary theories of ageing, stress, senescence-1 ike phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics // Mech. Ageing Dev. 2002. Vol. 123. P. 937-946.

 

Tower J. Transgenic methods for increasing Qrosophija life span // Mech. Ageing Dev. 2000. Vol. 118. P. I-14.

Truinin N., Kaye A. M., Berenbhonl. Influence of mutagens on initiation of skin carcinogenesis // Biochem. Pharmacol. 1964. Vol. 13. P. 263-267.

Trautner T. A., Swartz M. N., Komberg A. Enzymati synthesis of deoxyribo-nucleie acid. X. Influence of bromouracil substitution on replication // Proc. Natl. Acad. Sci. USA. 1962. Vol. 48. P. 449-^(55.

 

Trinei M., Giorgio M., Ctcatese A. et al. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis // Oncogene. 2002. Vol. 21. P. 3872-3878.

 

Troen a R. The biology of aging // The Maunt Sinai J. Med. 2003. VoL 70. P. 3-22.

Trosko J. E., Cluing С С, Wilson M. R. et al. Gap junctions ^nd regulation of cellular functions of stem cells during development and differentiation // Methods. 2000. Vol. 20. P. 245-264.

 

Tsujiuchi Т., Tsutsumi M., KidoA. et al. Induction of telomerase activity during regeneration after partial hepatectomy in the rat // Cancer Lett. 1998. Vol. 122. P. 115-120.

 

Tuljapurkar S., П N., Вое С. A universal pattern of mortality decline in the G7 countries//Nature. 2000. Vol. 405. P. 789-792.

Turrens J. F., Boveris A. Generetion of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria // Biochem. J. 1996. Vol. 320. P. 421-427.

 

TynerS. D., VenkatachalatnS., ChotJ. et al. p53 mutant mice that display early ageing-associated plicnotypcs // Nature. 2002. Vol. 415. P. 45-53.

Veda M. Telomerase in cutaneous carcinogenesis // J. Dermatol. Sci. 2000. Vol. 23, Suppl 1. P. S37-S40.

Uemura K., Castle S. C, Maldnodan T. The frail elderly: role of dendritic cells in the susceptibility of infection //Mech. Ageing Dev. 200Z Vol. 123. P. 955-962.

 

Vkraintseva S. V., Yashin A. I. How individual age-associated changes may influence huma morbidity and mortality patterns // Mech. Ageing Dev. 2001. Vol. 122. p. 1447-1460.

 

(Jlrich P., CeratniA. Protein glycation, diabetes, and aging // Recent Progr. Horm. Res. 2001. Vol. 56. P. 1-21.

ValteixS., JeannyJ. C, ElsevierS. et al. Expression of human FSB, a gene nested within the coagulation factor VIII gene, produces multiple eye defects and developmental alterations in chimeric and transgenic mice // Hum. МЫ. Genet. 1999. Vol. 8. P. 1291-1301.

 

Van Duuren B. L, Sivak A., Katz C. et at. The effect of aging and interval between primary and secondary treatment in two-stage carcinogenesis on mouse skin // Cancer Res. 1975. Vol. 35. P. 502-505.

 

Van Someren E, J. W., Raymann R. J. E. M., ScherderE. J.A., et al, Orcadian and age-related modulation of thermoreoeption and temperature regulation: mechanisms and functional implications // Ageing Res. Rev. 2002. Vol. 1. P. 721-778.

 

Van Steeg H., Klein H., Beems R. В., van Kreijl С F. Use of DNA repair-deficient XPA transgenic mice in short-term carcinogenicity testing//Toxicol. Pathol. 1998. Vol. 26. P. 742-749.

 

Van Steeg H., MuttendersL. H. F., VijgJ. Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice // Mutat. Res. 2000. Vol. 450. P. 167-180.

 

Van Voorhies W. A., Ward S. Genetic and environmental conditios that increase longevity in Caenorhabditis elegans decrease metabolic rate // Proc. Natl. Acad. Sci. USA. 1999. Vol. 96. P. 11399-11403.

 

Vanyushin B. F., Nemimvsky L E., Klimenko V, V. et at. The 5-methylcytosine in DNA of rats//Gerontologia. 1973. Vol. 19. P. 38-152.

Vasile E, Totnita K, Brown L F. etai. Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis// FASEB J. 2001. Vol. 15. P. 458-466.

 

Vaupel J. W., Carey J. R., Christensen K. et ai Biodemographic trajectories of longevity // Science. 1998. Vol. 280. P. 855-860.

Vaupel J. W., Yashin A. I. Heterogeneity's rises: some surprising effects of selection on population dynamics //Am. Stat. 1985. Vol.39. P. 176-185.

Velculescu V. E, Madden S. L., Zhang L. et at Analysis of human transcrip-tomes // Nat. Genet 1999. Vol. 23. P. 387-388.

Vijg J. Somatic mutations and aging: a re-evaluation // Mutat. Res. 2000. Vol. 447. P. 117-135.

Vijg J., Dolle M. E. T. Large genome rearrangements as a primary cause of aging// Mech. Ageing Dev. 2002. Vol. 123. P. 907-^15.

Vlassara H., Bucala R., Striker L. Pathogenic effects of advanced glycosylation: biochemical, biologic and clinical implication for diabetes and aging // Lab. Invest. 1994. Vol. 70. P. 138-151.

 

Vleck С M., Haussmann M. F., Vieck D. The natural history of telomere: tools for aging animals and exploring the aging process // Exp. Gerontol. 2003. Vol. 38. p. 791-795.

 

Vogel H., Litn D.-S., KarsentyG. et al. Deletion of Ku80 causes early onset of senescence in mice // Proc. Natl, Acad. Sci. USA. 1999. Vol.96, p. 10770-10775.

 

Von Zglinicki T. Oxidative stress shortens telomeres // Trends Biochem. Sci. 2002. Vol. 27. P. 339-344.

Von Zglinicki Т., Burkle A., Kirkwood T. B. L. Stress, DNA damage and ageing - an integrative approach // Exp. Gerontol. 200t Vol. 36. P. 1049- 1062.

Wagner M., Hampel В., Bernhard D, et at. Replicative senescence of human endothelial cells in vitro involves Gl arrest, polyploidization and senescence-associated apoptosis//Exp. Gerontol. 2001. Vol.36. P. 1327-1347.

 

Watford R. L ITie Immunological Theory of Aging. Copenhagen: Muksgaard, 1969. 338 p.

Walford R.L, SpindlerS.R. The response to caloric restricton in mammals shows features also common to hibernation: a cross-adaptation hypothesis // J. Gerontol. A Biol. Sci. Med. 1997. Vol. 52. P. Bi79-B183.

 

Walter C. A., Grttbowski D. Т., Street K. A. et at. Analisys and modulation of DNA repair in aging // Mech. Ageing Dev. 1997. Vol. 98. P. 203-222.

Walter С. A., Intano G. W., McCarrey J. R. et al. Mutation frequency declines during spermatogenesis in young mice but increases in old mice // Proc. Nat!. Acad. Sci. USA. 1998. Vol. 95. P. 10015-10019.

 

Wang E. Failure to undergo programmed cell death in senescent human fibro-blasts in related to inability to downregulate bcl2 presence // Cancer Res. 1995. Vol. 55. P. 2284-2292.

 

Wang E. Regulation of apoptosis resistance and ontogeny of age-dependent diseases // Exp. Gerontol. 1997. Vol. 32. P. 471-484.

Wang J., Hannon G. J., Beach D. H. Risky immortalization by telomerase // Nature. 2000. Vol. 405. P. 755-756.

Ward A., Bates P., Fisher R. et al. Disproportionate growth in mice with Igf-2 transgenes// proc. Natl. Acad. Sci. USA. 1994. Vol. 91. P. 10365-10369.

Ward J. M. Background data and variations in tumor rates in control rats and mice // Prog. Exp. Tumor Res. 1983. Vol. 26. P. 241-258.

Ward J. M. Increased susceptibility of liver of aged F.344/Ncr rats to the effects of phenobarbital on the incidence, morphology, and histochemistry of hepatocellular foci and neoplasms//J. Natl. Cancer Inst. 1983. Vol. 71. P. 815-$23.

 

Wardi M., Anver M. R., MaHer J. F., Devor-HennemanD. E. Pathololgy of mice commonly used in genetic engineering (C57BL/6; 129; B6, 129; and FVB/n) // J. M. Ward, J. F. Mahler, R. R. Maronpot et al. Pathology of Genetically Engineered mice. Ames: Iowa State Univ. Press. 2000. P. 16(-178.

 

Ward J. M.t Henneman J. R., Osipova G. K, Anisimov V. N. Persistence of 5-bromo- 2'~ deoxyuridine in tissues of rats after exposure in early life // Toxicology. 1991. Vol. 70. P. 345-352.

 

Ward J. M., Lynch P., Riggs C. Rapid development of hepatocellular neoplasms in aging male СЗН/HeNcr mice given phenobarbital // Cancer Lett. 1988. Vol. 39. P. 9-18.

 

Wamer H. ft., fngram D., Miller R. A. et al. Program for testing biological interventions to promote health aging // Mech. Ageing Dev. 2000. Vol. 155. P. 199-208.

 

Warner H. R. Aging and regulation of apeptosis//Curr. Top. Cell. Regul. 1997. Vol. 35. P. 107-121.

Warner H. R., Sierra F. Models of accelerated ageing can be informative about the molecular mechanisms of ageing and/or age-related pathology // Mech. Ageing Dev. 2003. Vol. 124. In press.

 

Watanabe A., Shibata S., Watanabe S. Orcadian rhythm of spontaneous neu-ronal activity in the suprachiasmaiic nucleus of old hamster in vitro // Brain Res. 1995. Vol. 695. P. 237-239.

 

Waxier S. H., Brecher G., Beat S. L The effect of fat-enriched diet on the incidence of spontaneous mammary tumors in obese mice // Proc. Soc. Exp. Biol. Med. 1979. Vol. 162. P. 365-368.

 

Weeda G., Donker L, de WitJ. et ai Disruption of mouse ERCCl results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence // Curr. Biol. 1997. Vol. 7. P. 427-439.

 

Wet Q. Effect of aging on DNA repair and skin carcinogenesis: a minireview of population-based studies //J. Investig.Dermatol.Symp. Proc. 1998. Vol.3, N 1. P. 19-22.

 

Wei W., SedivyJ. M. Differentiation between senescence (Ml) and crisis (M2) in human fibroblast cultures // Exp. Cell Res. 1999 Vol. 253. P. 519-522.

Weindruch R., Kayo 71, Lee С К., Prolla Т. A. Gene expression profiling of aging using DNA microarrays//Mech. Ageing Dev. 2002. Vol. 123. P. 177-193.

Weindruch R., Kayo Т., Lee C. K. Prolla T.A. Mkroarray profiling of gene expression in aging and its alteration by caloric restriction in mice // J. Nutr. 2001. Vol. 13I.P. 918S-923S.

 

Weindruch R., SohalR. $. Caloric intake and aging // The New Engl. J. Med. 1997. Vol. 337. P. 986-994.

Weindruch R., Watford R The Retardation of Aging and Disease by Dietary Restriction. Springfield, Ш: С С Thomas, 1988. 310 p.

Weismann A. Essays Upon Heredity and Kindred Biological Problems. Oxford: Claderon Press. 1889.

Welle S. Gene transcript profiling in aging research. Exp. Gerontol. 2002. Vol. 37. P. 583-590.

Weng N., Palmer L. D., Levine B. L. et at. Tales of tails: regulation of telomere lenght and telomerase activity during lypmhocyte developent, differentiation, activation, and aging//Immunol. Reviews. 1997. Vol. 160. P. 43-54,

 

WestendorpR. G, KirkwoodT. B. L. Human longevity at the cost of reproductive success//Nature. 1998. Vol. 396. P. 743-746.

Whytaker Azmitia P. M., Wingate M. et at. Transgenic mice overexpressing the ncurotrophic factor S-100 (show neuronal cytoskeletal and behavioral signs of altered aging processes: implications for Alzheimers disease and Down's syndrome // Brain Res. 1997. Vol. 776. P. 51-60.

 

Williams G. С Natural selection, the cost of reproduction and refinement of Lack's principle. Am. Natur. 1966. Vol. 100. P. 687-690.

Williams G. C. Pleiotropy, natural selection and the evolution of senescence // Evolution. 1957. Vol. 11- P. 398-411.

Wilson M., Jones P. A. DNA methylation decreases in aging but not in immortal cells//Science.l983.Vol.220.P. 1055-1057.

Winter J. C. The effect of an extract of Ginkgo biloba, Egb 761, on cognnitive behavior and longevity in the rat//Physiol. Behavior. 1998. Vol. 6. P. 425-433.

 

Wise P. M., Smith M.J., Dubai D.B. et at. Neuroendocrine modulation and repercussions of female reproductive aging // Recent Prog. Horm. Res. 2002. Vol. 57. P. 235-256.

 

Wolf E., Kahnt E., Ehrtein J. Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons from transgenic animal models // Mech. Ageing Dev. 1993. Vol. 68. P. 71-87.

 

World Health Organization. Health of the Elderly. Tech. Rep. Ser. 1989. N 779.

World Health Organization. Health Policy Aspects of Aging. World Assembly onAgeing; 1982; Vienna, Geneva: WHO (A/CONF. 113/19).

Wriglti W. E, Sliay J.W. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology // Nature Medicine. 2000. Vol. 6. P. 849-851.

 

Wynford-Viotnas D. Cellular senescence and cancer Hi. Pathol. 1999. Vol. 187. P. 100-111.

Wynford-Thotnas D., BondJ. A., Wyllie F. S., Jones CJ. Does telomere shortening drive selection forp53 mutation inhuman cancer? //Mol. Carcinogenesis. 1995. Vol. 12. P. 119-123.

 

XteH. Q., Ни V. W. Modulation of gap junctions in senescent endothelial cells // Exp. Cell Res. ]994. Vol. 214. P. 172-176.

Xu L, Bard M. Z Enhanced potential for oxidative stress in hyperinsulinemic rats: imbalance between hepatic peroxisomal hydrogen peroxide production and decomposition due to hyperinsulinemia // Horm. Metab. Res. 1999. Vol. 31. P. 278-282.

 

Yatnasaki H., Krutovskikh V., Mesntl M. et al. Role of connexin (gap junction) genes in cell growth control and carcinogenesis // C. R. Acad. Sci. III. 1999. Vol. 322. P. 151-159.

 

Yang A., Walker N, Bmnson ft, etal. p73-deficient mice have neurological, phc-romonal and inflammatory defects but lack spontaneous tumours // Nature. 2000. Vol. 404. P. 99-103.

 

Yang F., Ueda K., Chen P. et al. Plaque-associated -synuclin (NACP) pathology in aged transgenic mice expressing amyloid precursor protein// Brain Res. 2000. Vol. 853. P. 381-383.

 

Yang J. r, Chang E., Cherry A. M. et al Human endothelial cell life extension by telomeraseexpression III. Biol.Chem. 1999. Vol. 274. P. 26141-26148.

Yashin A. I., lashine I, A. How frailty models can be used for evaluating longevity limits: taking advantage of an interdisciplinary approach // Demography. 1997. Vol. 34. P. 31-48.

 

Yashin A. I., Manton K. G. Effects of unobserved and partially observed covari-ate processes on system failure: A review of models and estimation strategies // StaL Sci. 1997. Vol. 12. P. 20-34.

 

Yashin A. I., Begun A. S., Boiko S. I. et aL New age patterns of survival improvement in Sweden: do they characterize changes in individual aging? // Mechr Ageing Dev. 2002. Vol. 123. P. 637-647.

 

Yashin A. I., Cysper J. R,. Johnson T, B, et al. Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans II Mech. Ageing Dev. 2001. Vol. J2Z P. 1477-1495.

 

Yashin A. f., De Benedicth C, VaupetJ. et at. Genes and longevity: lessons from Centenarian Studies//J. Gerontol. Biol. Sci. 2000. Vol. 55A. P. Bl-B10.

 

Yashin A. I., De Benedictis G., Vaupet J. et al. Genes demography and life span: the contribution of demographic data in genetic studies of aging and longevity // Am. J. Human Genet. 1999. Vol. 65. P. j 178-1193.

 

Yashin A. I., (Jkraintseva S. V., De Benedictis G, Anisitnov V. N. et at. Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends m survival// J. Geront. Biol. Sci. 2001. Vol. 56A. P. B432-B442.

 

Yegorov Y. E, Akimov S. S., Hass R. et al. Endogenous beta-galactosidase activity in continuously nonproliferating cells // Exp. Cell Res. 1998. Vol.243. P. 207-211.

 

Yegorov Y. E., Semenova 1. V., Kamchentsev D. N. et al. Senescent accelerated mouse (SAM): a model that binds in vjvo and in vitro aging // J. Anti-Aging Med. 2001. Vol. 4. P. 39-47.

 

Young R. A. Biomedical discovery with DNA arrays // Cell. 2000. Vol. 102. P. 9-15.

YoussefJ. A., Bouziane M., Badr M. Z Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo // Mech. Ageing Dev. 2003. Vol. 124. P. 333-340.

 

Yu B.P., ed. Free Radicals in Aging. Boca Raton: CRC Press, Inc, 1993.

Yu B. P. Aging and oxidative stress: Modulation by dietary restriction // Free Radicals Bid. Med. 1996. Vol. 21. P. 651-668.

Yu B. P. Modulation of Aging Processes by Dietary Restriction. Boca Raton: CRC Press, 1994. 264 p.

Yuasa Y. DNA methylation in cancer and aging // Mech. Ageing Dev, 2002, Vol. 123. P. 1649-1654.

Zalensky A. O., Totwiin N. V., Zalenskaya I. A. el at. Telomere-telomere interactions and candidate telornere binding protein(s) in mammalian sperm cells // Exp. Cell Res. 1997. Vol. 232. P. 29-41.

 

Zatz M. M., Goldstein A. L Thymosins, lymphokines and the immunology of aging//Gcrontology.(985. Vol. 31. P. 263-277.

Ziiang Y., Herman B. Ageing and apoptosis // Mech. Ageing Dev. 2002. Vol. 123. P. 245-260.

Zliou Т., Edwards C. K., Mountz J.D. Prevention of age-related T-apoptosis defect in CD2-ras-transgenic mice// J. Exp. Med. 1995. Vol. 182.P. 129-137.

Zi-Nagy I., Harmon D., Kttani K., eds. Pharmacology of Aging Process. Methods of Assessment and Potential Interventions // Ann. N. Y. Acad. Sci. 1994. Vol. 717.

 

 

См. также:

    Предисловие

    Часть I. Молекулярные и клеточные механизмы старения

    Часть II. Физиология и патология старения

    Часть III. Модифицирующие факторы старения как средства для изучения его механизмов

    Часть IV. Механизмы старения: демографические и теоретические аспекты

    Часть V. Фундаментальная геронтология: приоритеты и перспективы

    Список сокращений

 

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